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Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity
Date:2/7/2008

Company Continues to Lead Tropism Testing Field

SOUTH SAN FRANCISCO, Calif., Feb. 7 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc (Nasdaq: MGRM) today announced that data related to the company's advanced HIV tropism assay have been presented as multiple posters during the 15th Conference on Retroviruses and Opportunistic Infections (CROI) this week in Boston, MA. Highlights from the meeting include data on an enhanced version of the Trofile(TM) Assay's superior ability to identify patients that are not likely to respond to CCR5 antagonist therapy, as well as data that sheds new light on how patients develop resistance to this new class of drugs.

During the "Emerging Patterns of Resistance to New Antiretrovirals" session at CROI, Monogram participated in a number of poster presentations, including:
-- An Enhanced Version of the Trofile HIV Co-receptor Tropism Assay

Predicts Emergence of CXCR4 Use in ACTG5211 Vicriviroc Trial Samples

-- Emergence in vivo of Vicriviroc Resistance in HIV-1 Subtype C: Role of

V3 Loop and Susceptibility to Other CCR5 Antagonists

-- Changes in V3 Loop Sequence Associated with Failure of Maraviroc

Treatment in Patients Enrolled in the MOTIVATE 1 and 2 Trials

The first presentation analyzed subjects from the AIDS Clinical Trials Group 5211 study and compared co-receptor tropism results (R5, X4 or dual/mixed DM HIV) of the original Trofile test with those obtained using an enhanced version of the assay. Researchers found that the enhanced Trofile assay would have further optimized patient selection for this new drug class by successfully identifying patients with low levels of DM (non R5) HIV at screening and who subsequently exp
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SOURCE Monogram Biosciences, Inc
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