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Data Presented at ASH Annual Meeting Indicates the Potential of T-Cell Engaging BiTE Antibody Blinatumomab as a Consolidation Treatment for Aggressive Leukemias
Date:12/8/2008

high likelihood of relapse," commented Professor D. Hoelzer, chairman of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia (GMALL). "The ability to convert a patient's MRD status from positive to negative could lead to better clinical outcomes. These data suggest that blinatumomab may hold the potential to be an effective consolidation therapy after prior incomplete response to chemotherapy or even targeted therapy."

"The level of response to blinatumomab in ALL patients observed in this trial combined with the unmet need for new therapies to treat this patient population may open the path towards an accelerated development in this indication," commented Micromet Senior Vice President and Chief Medical Officer Carsten Reinhardt, M.D.

Micromet will hold a webcast and conference call on Monday, December 8 at 2:00 pm EST to discuss this study and other blinatumomab data presented at the conference. To access the webcast and view the PowerPoint presentation, please log on to: http://webcasts.micromet-inc.com. To participate in the conference call, dial 866-700-7441 (U.S.) or 617-213-8839 (international), passcode: 39298646.

About BiTE Antibodies

BiTE(R) antibodies are designed to direct the body's cytotoxic, or cell- destroying, T cells against tumor cells, and represent a new therapeutic approach to cancer therapy. Typically antibodies cannot engage T cells because T cells lack the appropriate receptors for binding antibodies. Previous attempts have shown the potential of T cells to treat cancer, but the therapeutic approaches tested to date have been hampered by cancer cells' ability to escape recognition by T cells. The use of BiTE antibodies that are specifically designed to engage T cells for attacking cancer cells may provide a more effective anti-tumor approach than conventi
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SOURCE Micromet, Inc.
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