Navigation Links
Data From a Head-to-Head Crossover Study Evaluating FOSRENOL(R) and Sevelamer Published Today
Date:10/7/2009

DUBLIN, October 7 /PRNewswire-FirstCall/ --

- For Medical and Healthcare Media Only -

- Direct Comparison of the Two non-Calcium Phosphate Binders Gives new Insights Into Relative Efficacy

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, today announces the publication in Clinical Nephrology of findings from a head-to-head clinical study comparing the efficacy of two non-calcium based phosphate binders, FOSRENOL(R) (lanthanum carbonate) and sevelamer hydrochloride (Genzyme's Renagel(R)) in chronic kidney disease (CKD) patients on haemodialysis.

In this 12-week crossover study, patients (n=182) were randomized to receive either FOSRENOL or sevelamer for four weeks, and then switched to the alternative phosphate binder for the same period. Product doses were pre-defined to allow a direct efficacy comparison. Doses were based on those used in previous clinical trials[1,2] and established clinical practice.[3]

The study's primary endpoint, change in serum phosphorus from baseline to end of treatment, was evaluated using several statistical analyses; the primary analysis used last observation carried forward (LOCF) for the intention to treat (ITT) population (n=174), meaning that if a patient dropped out of the study during treatment, their last post baseline serum phosphorus measurement was used as the end of treatment value. The pre-determined key secondary analysis assessed the completer population; defined as those patients who had completed four weeks' treatment with both phosphate binders and had a serum phosphorus value at the end of treatment.[4]

The analysis of LOCF for the ITT population showed a numerically greater reduction in serum phosphorus with FOSRENOL (1.7mg/dL) versus sevelamer (1.4mg/dL), although
'/>"/>

SOURCE Shire Plc
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. New Data From Head-to-Head Phase 3 Trial Demonstrate That Liraglutide is More Effective Than Exenatide in Treatment of Type 2 Diabetes
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Kline Study: Better Brushing Habits Boost European Oral Care Sales
5. Evotec to Present Details of the Positive Phase II Study in Insomnia With EVT 201 at the Worldsleep07 Congress in Cairns/Australia
6. NASA study will help stop stowaways to Mars
7. New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome
8. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
9. Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201
10. Study Supports Use of GlycoMark Blood Test to Evaluate Therapy in Children with Diabetes
11. Quigley Corporation Releases Update on Quigley Pharmas Phase IIb Clinical Study of QR-333 in Diabetic Peripheral Neuropathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Cellgen Diagnostics today launched ... a corporate lab for its genetic-based medical testing ... a critical component in the move from today’s ... of personalized medicine – a more predictive, preventive, ... contributions will support Cellgen’s intent to develop the ...
(Date:8/19/2014)... , Aug. 19, 2014 CSSi, the ... industry, recently announced the formation of the company,s Medical ... announce the addition of Dr. William E. Gannon, ... http://photos.prnewswire.com/prnh/20140818/136957 The MCAB, with ... variety of therapeutic areas and set strategic goals for ...
(Date:8/18/2014)... (PRWEB) August 19, 2014 2014 ... Industry” is a professional and in-depth research report ... basic Linalool information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:8/18/2014)... UPTON, NYElectronic devices with unprecedented efficiency and ... materials that use built-in electric polarizations to ... magnets inside most popular data-driven technology. But ... stumbling blocks, including a curious habit of ... at the U.S. Department of Energy,s Brookhaven ...
Breaking Biology Technology:Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4
... REDWOOD CITY, Calif., Sept. 4 Cardica, Inc. ... 2009, it received a notice from the Listing Qualifications Department ... stock will be delisted from NASDAQ based upon NASDAQ staff,s ... $10 million stockholders, equity requirement for continued listing on the ...
... BEIJING, Sept. 4 /PRNewswire-Asia/ -- Sinovac Biotech ... biopharmaceutical products in China, announced today that,the Ministry of ... has issued the initial order to Sinovac to purchase ... initial order, Sinovac is,required to complete the production of ...
... , SEATTLE, Sept. 4 On the day that ... in the Black Rock Desert, partiers will see a giant marijuana bud ... which has already flown over Seattle Hempfest and San Francisco, features a ... Sugary Buds?" , , The controversial banner is the ...
Cached Biology Technology:Cardica Receives NASDAQ Notification of Non-Compliance 2Sinovac Obtains Initial Order of H1N1 Vaccine from Chinese Central Government 2Sinovac Obtains Initial Order of H1N1 Vaccine from Chinese Central Government 3Nevada Burning Man Festival Sees Giant Aerial Marijuana Bud Banner That Protests Hydroponics Hijacking 2Nevada Burning Man Festival Sees Giant Aerial Marijuana Bud Banner That Protests Hydroponics Hijacking 3
(Date:8/19/2014)... (Boston) Some infants born with neonatal abstinence ... a more difficult time going through withdrawal than ... understood. While genetic and epigenetic (when genes are ... identified as potential factors, researchers at Boston University ... (BMC) conducted a first of its kind study ...
(Date:8/19/2014)... fizzy soda knows that bubbles can throw tiny particles ... industrial applications, Princeton researchers have demonstrated that the bursting ... well. , "It is well known that bursting bubbles ... to discover that when we covered the water with ... the water," said Howard Stone, the Donald R. Dixon ...
(Date:8/19/2014)... study that analyzed concentrations of African dust transported ... winter and spring. These research findings offer new ... quality impacts of African dust, including the climate ... occur from increased African dust emissions in the ... (UM) Rosenstiel School of Marine and Atmospheric Science ...
Breaking Biology News(10 mins):In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2Bubbling down: Discovery suggests surprising uses for common bubbles 2Bubbling down: Discovery suggests surprising uses for common bubbles 3Study of African dust transport to South America reveals air quality impacts 2
... disease, one of the most important emerging diseases in ... lymph nodes, triggering a significant immune response, but one ... report researchers at the University of California, Davis. ... why some people experience repeated infections of Lyme disease. ...
... largest fire in the history of the state of Arizona ... satellite data from a variety of instruments to plan their ... out. The Landsat 5 satellite captured images of ... Arizona on June 15, 2011 at 19:54:23 Zulu (3:54 p.m. ...
... three-dimensional plasmon rulers, capable of measuring nanometer-scale spatial ... researchers with the U.S. Department of Energy (DOE),s ... with researchers at the University of Stuttgart, Germany. ... unprecedented details on such critical dynamic events in ...
Cached Biology News:Lyme disease bacteria take cover in lymph nodes 2Landsat 5 satellite helps emergency managers fight largest fire in Arizona history 2Taking the 3-D measure of macromolecules: 2Taking the 3-D measure of macromolecules: 3
... SB3, Fully adjustable mixing angle, Variable speed, ... hold a number of different sized tubes, ... aerating cultures, keeping biological samples in suspension ... can be used in incubators up to ...
...
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
Fingerprinting II cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to the Fingerp...
Biology Products: