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Daclizumab shows potential for new immunoregulatory approach to treating MS
Date:2/16/2010

#946; group (p=0.51, 95% CI -76%, 68%). Daclizumab reduced MS lesion activity as early as week four with an average of 2.1 new or enlarged MS lesions appearing in the placebo/IFNβ group versus 0.9 new or enlarged MS lesions for the DAC high dose/IFNβ group.

Daclizumab treatment was generally well-tolerated. Common adverse events were similar in all treatment arms. Grade 3 adverse events were observed in 24 percent of DAC/IFNβ-treated patients and 14 percent of placebo/IFNβ-treated patients. The most frequent grade 3 adverse events were infections, which occurred in 7 percent of DAC/IFNβ-treated patients and 3 percent of placebo/IFNβ-treated patients. There were no opportunistic infections or deaths, and all infections resolved with standard therapies.


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