Navigation Links
Daclizumab shows potential for new immunoregulatory approach to treating MS
Date:2/16/2010

Cambridge, Mass. and Redwood City, Calif. February 16, 2010 Biogen Idec (NASDAQ: BIIB) and Facet Biotech Corporation (NASDAQ: FACT) today announced the publication of Phase 2 data showing that the addition of daclizumab to interferon beta (IFNβ) led to a significant reduction in the number of new or enlarged multiple sclerosis (MS) lesions when compared to IFNβ alone in patients with active relapsing forms of MS. The trial, called CHOICE, also showed that daclizumab led to an increase in a subset of the natural killer (NK) cells that help regulate the immune system. These data were published in Online First, the online edition of The Lancet Neurology, and will be published in the April issue of the Lancet Neurology.

Study results showed that daclizumab 2mg/kg administered subcutaneously every two weeks in combination with IFNβ reduced the number of new or enlarged gadolinium contrast-enhancing lesions (Gd-CELs) by 72 percent versus IFNβ therapy alone. The presence of Gd-CELs is thought to indicate inflammation within the central nervous system that corresponds with MS disease activity. In addition, treatment with daclizumab resulted in a seven- to eight-fold increase of CD56bright NK cells, which was associated with a decrease in disease activity. Daclizumab was well-tolerated in the CHOICE trial and common adverse events occurred with a similar frequency in each of the treatment groups.

"The CHOICE trial demonstrated that daclizumab was associated with a robust increase in important cells that help regulate the immune system, as well as a significant reduction in MS lesion formation," said John W. Rose, M.D., professor of Neurology, Research Laboratory, Veterans Affairs Salt Lake City Health Care System and the University of Utah, and an author on the manuscript. "Previous studies have shown that people with MS have less of these immunoregulatory cells than people without MS which, coupled with the reduction in
'/>"/>

Contact: Kate Weiss
617-914-6524
GCI Health
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy
2. Mescal worm test shows DNA leaks into preservative liquids
3. Boost for Prostate Cancer Screening - Report Shows Mortality Reduction as High as 31%
4. Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy
5. UCBs Cimzia(R) (certolizumab pegol), Shows Rapid and Sustained Clinical Response in Adult Patients Living with Moderate to Severe Rheumatoid Arthritis
6. Tiny test tube experiment shows reaction of melting materials at the nano scale
7. New Survey Shows Devastating Impact of Rheumatoid Arthritis Pain on Intimate Relations
8. Topical erectile dysfunction therapy shows promise
9. Study on keeping nuclear bombs from US ports shows misplaced fear over cargo scanning cost
10. Medicagos H1N1 pandemic vaccine candidate shows positive response in 100% of vaccinated animals after a single dose
11. Video shows nanotube spins as it grows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Boston, MA (PRWEB) August 28, 2014 ... of wholesale construction materials, selected SoundConnect ... of their cloud based audio and web conferencing ... configured to support PrimeSource’s employees’ needs. SoundConnect ... technologies. , PrimeSource Building Products will be ...
(Date:8/27/2014)... 2014 Green & Grow Inc. (GGI) ... funding and secured Otter Capital as a significant new ... commercialization of GGI’s Agriplier™ technology, building on recent compelling ... “Since our first meeting, we have been impressed with ... space,” said Alan Sobba, President and CEO of GGI. ...
(Date:8/27/2014)... Aug. 27, 2014   MSC , a healthcare ... today announced the appointment of Mary Beth Loesch ... 28 years of experience preparing companies for rapid growth ... Executive Vice President of Corporate Development and Healthcare. In ... business , as well as corporate strategy and marketing. ...
(Date:8/27/2014)... -- Research and Markets  has announced the ... Polymer, Food & Beverage, Personal Care & Pharmaceutical) ... report to their offering. Lactic acid ... carbon atom. The main applications of lactic acid ... personal care product, and pharmaceutical industries. Lactic ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2
... Health Care Forum discusses the future of Continuing ... ... Accredited online nursing courses,are replacing traditional classroom-based courses, offering nurses ... options., Ann Johnson, CEO of Wild Iris Medical Education took ...
... 2 Simbionix has announced the,release of a ... simulator that,gives trainees hands-on experience with different techniques ... tubal,sterilization and oophorectomy., The GYN module is ... developed for the LAP Mentor, the world,s most ...
... Japan and UNION CITY, Calif., June 2 ... that the two,companies have entered into a research ... and Asian development and,commercialization of sirolimus for the ... related macular degeneration (wet AMD) and,diabetic macular edema ...
Cached Biology Technology:Modernizing Continuing Education With Online Courses 2Simbionix Takes Non-Invasive GYN Surgical Training to the Next Level 2Santen and MacuSight Announce Collaboration and License Agreement for Sirolimus in Ocular Diseases and Conditions 2Santen and MacuSight Announce Collaboration and License Agreement for Sirolimus in Ocular Diseases and Conditions 3
(Date:8/27/2014)... has shown that piglets can be weaned later with ... outcome of the study at the University,s Roseworthy campus, ... is an important finding for pig producers. It allows ... production. , "Sows don,t usually start their oestrous cycles ... piglets have been weaned," says Ms Alice Weaver, PhD ...
(Date:8/27/2014)... finds , Gamblers show the same tendencies as ... shown. , Researchers, led by Dr Elliot Ludvig of ... that found that both human gamblers and pigeons were ... rewards. , Published in Biology Letters , the ... role that memories of previous biggest wins and losses ...
(Date:8/26/2014)... Like a protective tent over a colony of ... infections especially difficult. Microorganisms protected in a biofilm ... antibiotic resistance and recalcitrance to treatment, and biofilm-protected ... bacterial infections in humans and are 50 to ... bacterial infections. , "In essence, we may have ...
Breaking Biology News(10 mins):Piglet weaning age no bar to litter frequency 2Gamblers are greedy bird-brains, University of Warwick research finds 2Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... MARC (Maximizing Access to Research Careers) Program has announced ... Conferences held in July, 2013. These awards are meant ... and scientists into the mainstream of the basic science ... at the FASEB Science Research Conferences. This year MARC ...
... MARC (Maximizing Access to Research Careers) Program has announced ... Study of Reproduction meeting in Montreal, Canada from July ... entry of students, postdoctorates and scientists from underrepresented groups ... to encourage the participation of young scientists at the ...
... 2011 and 2012, research from China,s Nanjing University made ... of genetic material from the plants they,d ingested could ... animals, own genes off. The surprising results from Chen-Yu ... one day be treated with medicinal food, but also ...
Cached Biology News:Hold the medicinal lettuce 2Hold the medicinal lettuce 3
Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
fli-1...
Vesicle Associated Membrane Protein (VAMP 1/2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Biology Products: