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DURECT Corporation Announces Fourth Quarter and Year End 2010 Financial Results
Date:3/2/2011

onsibility for non-clinical and CMC activities which had been previously jointly controlled and funded by DURECT and Nycomed.  If Nycomed elects to continue European development of POSIDUR after evaluation of BESST data, under the terms of the amendment, DURECT and Nycomed would resume joint control and financial responsibility of the non-clinical and CMC activities for the E.U. and the U.S.During 2010, we enrolled patients in our U.S. pivotal Phase III clinical study known as BESST (Bupivacaine Effectiveness and Safety in SABER Trial).  We expect to complete enrollment of BESST, comprising approximately 300 patients, in the first half of 2011.  POSIDUR is our post-operative pain relief depot that utilizes our patented SABER technology to deliver bupivacaine to provide up to three days of pain relief after surgery. POSIDUR is licensed to Hospira for commercialization in the U.S. and Canada, and to Nycomed for commercialization in Europe and other defined countries. We have retained commercialization rights in Japan and all other countries not subject to the Nycomed and Hospira licenses.


  • ELADUR (TRANSDUR®-Bupivacaine).  Pfizer completed its acquisition of King in February 2011 and as a result has assumed the development and commercialization rights and obligations to ELADUR.  In April 2010, King Pharmaceuticals initiated a Phase IIb trial evaluating the safety and efficacy of ELADUR in approximately 260 patients with chronic low back pain.  We expect to receive top-line results from that study in the first half of 2011.ELADUR is our proprietary transdermal patch intended to deliver bupivacaine for a period of up to three days from a single application.  


  • TRANSDUR-Sufentanil.  During 2010, we conducted new market research on this product opportunity and have been incorporating that information in developing revised potential development pla
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