Navigation Links
DNA2.0 Unlocks The Secrets Of Optimized Gene Design: Company Identifies Codon Choice Design Principles for Optimal Protein Expression
Date:9/14/2009

To achieve high levels of protein expression, many researchers have abandoned cloning in favor of synthetic genes, which can be acquired in a couple of weeks at a reasonable cost. Unlike a natural gene, a synthetic gene can be designed to use any codon to encode each amino acid. This has the potential to be a huge advantage, as most researchers have come to accept that "codon optimization" can affect protein expression. DNA2.0 has produced a set of gene optimization design algorithms that allow the company to reliably offer expression yields up to 50 times greater than competing approaches.

Menlo Park, Calif (PRWEB) September 14, 2009 -- DNA2.0, the leading gene synthesis and protein engineering company, today announced the results of breakthrough research that has enabled the company to identify the design principle by which codons may be chosen to optimize protein expression. DNA2.0's research, which is funded by a grant from the National Science Foundation, has produced a set of design algorithms that allow the company to reliably offer expression yields up to 50 times greater than competing approaches. The paper, "Design Parameters to Control Synthetic Gene Expression in Escherichia coli" appears today in the publication, PLoS ONE (http://dx.plos.org/10.1371/journal.pone.0007002).

To achieve high levels of protein expression, many researchers have abandoned cloning in favor of synthetic genes, which can be acquired in a couple of weeks at a reasonable cost. Unlike a natural gene, a synthetic gene can be designed to use any codon to encode each amino acid. This has the potential to be a huge advantage, as most researchers have come to accept that "codon optimization" can affect protein expression. However, since a protein can be encoded by many alte
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches
2. DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors
3. RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research
4. DNA2.0 Launches New Website: Enhanced Design and Free Bioinformatics Tools Demonstrate DNA2.0's Customer Focus
5. Operon Biotechnologies and DNA2.0 Announce Co-Marketing and Technology Development Partnership
6. Pizza tossing art unlocks secrets of tiny motors
7. DNA Study Unlocks Mystery to Diverse Traits in Dogs
8. Charging ahead: University of Houston team revealing secrets of electricity-producing materials
9. Graphene yields secrets to its extraordinary properties
10. Cracking the Code: Exclusive Conference to Reveal Secrets of Chinese Pharmaceutical Industry
11. Pharmaburst(R) 500: Optimized, Evolutionary ODT Performance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 Riviera Beach, Florida based ... creation of the Sancilio Scientific Advisory Board (SSAB). ... philosophy of looking to nature for pharmaceutical advancements, ... are based on sound scientific data, analyses, expertise ... provides a vehicle for SCI to receive peer ...
(Date:8/27/2014)... 2014 According to the 2013 Raw ... the look and feel of markets for raw materials ... ingredients will push for more branded, science-backed products.” , ... strong market growth in the last decade as consumers ... and cosmetics to fit a more ‘wellness’ lifestyle approach. ...
(Date:8/27/2014)... 27, 2014 Budding Biomedical Scientists ... University School participated in the Scientific Enrichment ... University’s School of Medicine . , ... unparalleled professional experience in the sciences and brings ... faculty and students for both academic and career ...
(Date:8/26/2014)... San Diego, CA, and Bellingham, WA (PRWEB) August ... nanoscience and optical engineering, visions for next-generation wearable ... Light 2015 among numerous highlights at this year’s ... in the San Diego, California, Convention Center. More ... suppliers last week attended conferences, courses, an exhibition, ...
Breaking Biology Technology:New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... For Rejection Of Legislation That Will Cost Vermonters Current ... to the Legislature and a full page ad in ... that a bill under consideration by the Vermont Legislature ... for biotechnology growth and development not only in New ...
... April 24 Dendreon Corporation (Nasdaq: DNDN ... at the American Urological Association,s (AUA) Annual Meeting in ... conference call:, , ... CDT - "A randomized, double-blind, placebo-controlled, multi-center, phase III ...
... April 23 Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ... Lead Independent Director, on behalf of the Amylin Board of ... Carl Icahn and Eastbourne Capital Management, L.L.C. to find a ... can reach a resolution that will be in the best ...
Cached Biology Technology:Regional Biotech Association Warns Legislation Would Make VT Least Friendly State in Nation for Biotechnology and Life Sciences 2Dendreon Announces Data Presentations and Webcast at AUA Annual Meeting 2Amylin Issues Statement in Response to Carl Icahn 2
(Date:8/26/2014)... environmental and social problems such as global warming ... or does the burden fall on our failure ... to a new study in the Journal ... burden for solving global problems from governments to ... , "When businesses convince politicians to encourage responsible ...
(Date:8/26/2014)... People for the Ethical Treatment of Animals (PETA) and ... be in Prague this week at the 9th World ... Sciences presenting original research on alternatives to the use ... well as studies identifying problems with current laboratory oversight ... from August 24 to 28, 2014, PETA and PISC ...
(Date:8/25/2014)... years ago this month, one of the first U.S. ... State University campus, striking some 2,000 people. A university ... data gathered at the time to gain insight into ... virus,s rapid spread across the university community., The fall ... came in to the university,s Health and Wellness Services ...
Breaking Biology News(10 mins):An inconvenient truth: Does responsible consumption benefit corporations more than society? 2WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3
... release is available in Spanish . First ... stink bug (BMSB) is now in at least 39 states, is ... threat to orchard fruits, garden vegetables and row crops. It,s no ... its top "invasive insect of interest." But help may ...
... 2013) Autism Speaks, the world,s leading autism science ... million in funding for 14 new research projects. To ... for research projects that advance understanding of the causes, ... "Autism Speaks continues in its steadfast ...
... Even as policy makers and health experts point to an ... and universities in the United States have dropped physical education ... student was required to take physical education and exercise requirements ... low of 39 percent, according to a new study. ...
Cached Biology News:Combating USDA's top-ranked invasive insect 2Autism Speaks awards $4.8 million for new research 2Autism Speaks awards $4.8 million for new research 3Autism Speaks awards $4.8 million for new research 4Autism Speaks awards $4.8 million for new research 5Physical education requirement at 4-year universities at all-time low 2Physical education requirement at 4-year universities at all-time low 3
... porcine) Endogenous potent vasoconstrictor peptide. ... and modulates vascular tonus. ET-1, ET-2, and ... endothelin genes. ET-2 and ET-3 are similar ... six amino acids, respectively. All three isopeptides ...
... provide two highly efficient methods of identifying ... preparation. By using the large-scale screen method ... do is to transfer partial colonies of ... plates into the solutions provided by the ...
GLP-1 (HYB 147-12)...
... KLH-conjugated, synthetic peptide corresponding to ... mouse p19ARF. The epitope ... 62-75. Clone 5-C3-1. Quality ... immunoblot. Stability ...
Biology Products: