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DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches
Date:6/10/2009

The use of codon optimization in gene synthesis has long been misunderstood. DNA2.0 has cracked the code on optimizing sequence design and has been awarded two US patents covering the technology. DNA2.0's approach goes beyond codon arrangement, so the company is introducing a new, more accurate category: gene optimization. The algorithm associated with this patent has been proven to increase protein expression yields by up to 50 times greater than competing approaches.

Menlo Park, Calif. (PRWEB) -- DNA2.0, the leading gene synthesis and protein engineering company, today announced that the U.S. Patent and Trade Office has awarded the company two patent applications covering DNA2.0's breakthrough gene optimization technology. The patents--application numbers 12/184,234 and 12/184,240--claim methods for designing synthetic genes to reliably increase levels of recombinant protein expression. DNA2.0's unique optimization algorithm enables the company to offer expression yields up to 50 times greater than competing approaches.

"These patents embody one of DNA2.0's unique competitive advantages," said Jeremy Minshull, President at DNA2.0. "When customers come to us for synthetic genes, they want those genes to express. The broad and fundamental claims in this patent, together with the absence of any related competing patents, speak to our leadership in designing genes for protein expression."

Expression of recombinant proteins is vitally important for modern biotechnology. Unfortunately, many proteins are difficult to express outside their original host and frequently hard to overexpress even within their native host. Optimizing a gene for expression by designing the most effective coding sequence is therefore essential. Despite the high value of sequence design,
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