Navigation Links
DNA Study Unlocks Mystery to Diverse Traits in Dogs
Date:6/23/2008

Discovery Offers Potential Benefits for Dogs and their Owners

ROCKVILLE, Md., June 23 /PRNewswire/ -- What makes a pointer point, a sheep dog herd, and a retriever retrieve? Why do Yorkshire terriers live longer than Great Danes? And how can a tiny Chihuahua possibly be related to a Great Dane?

(Photo: http://www.newscom.com/cgi-bin/prnh/20080623/AQM507)

Dogs vary in size, shape, color, coat length and behavior more than any other animal, and until now, this variance has largely been unexplained. Now, scientists have developed a method to identify the genetic basis for this diversity that may have far-reaching benefits for dogs and their owners.

In the cover story of tomorrow's edition of the science journal Genetics , research reveals locations in a dog's DNA that contain genes that scientists believe contribute to differences in body and skull shape, weight, fur color and length -- and possibly even behavior, trainability and longevity.

"This exciting breakthrough, made possible by working with leaders in canine genetics, is helping us piece together the canine genome puzzle which will ultimately translate into potential benefit for dogs and their owners," said study co-author Paul G. Jones, PhD, a Mars Veterinary(TM) genetics researcher at the Waltham(R) Centre for Pet Nutrition -- part of Mars(R) Incorporated, a world leader in pet care that has been studying canine genetic science for the past eight years. "By applying this research approach, we may be able to decipher how genes contribute to physical or behavioral traits that affect many breeds."

Dogs originally derived from the wolf more than 15,000 years ago -- a blink of the eye in evolutionary terms. Selective breeding produced dogs with physical and behavioral traits that were well suited to the needs or desires of their human owners, such as herding or hunting ability, coat color and body and skull shape and size. This resulted in the massive variance seen among the more than 350 distinct breeds that make up today's dog population. Until now, the genetic drivers of this diversity have intrigued scientists who have been trying to explain how and why the difference in physical and behavioral traits in dogs changed so rapidly from its wolf origins.

An international team of researchers, which included scientists at the National Human Genome Research Institute, the University of Utah, Sundowners Kennels in Gilroy, California and Mars' Waltham Center for Pet Nutrition in the United Kingdom, studied simple genetic markers known as Single Nucleotide Polymorphisms, or SNPs, to find places in the dog genome that correlate with breed traits. Because many traits are "stereotyped" -- or fixed within breeds -- researchers can zero in on these "hot spots" to see what specific genes are in the area that might contribute to differences in traits.

The research used 13,000 dog DNA samples provided by Mars Veterinary, which holds one of the most comprehensive canine DNA banks in the world. This collection has been built up with the help of pet owners who have consented to their pets providing cheek swabs and blood samples for the database. Mars' DNA bank allowed the study to cover most of the American Kennel Club recognized breeds that span a wide variety of physical and behavioral traits and differences in longevity.

"With further refinement and additional data, this method could be used to tailor products that may benefit the health of pets," Jones said. "Pet owners and veterinarians may be able to develop better care regimes based on this knowledge. In addition, genetic information about behavioral traits, such as trainability and temperament, could also help veterinarians identify the most lifestyle-appropriate pet for an owner."

This research may also have implications for human health, as dogs suffer from many of the same diseases that we do.

Mars is continuing its commitment to canine genetic science with ongoing investigations to better understand the makeup of a dog's DNA to help benefit the lives of dogs and their owners. The Wisdom Panel MX(TM) mixed breed analysis test is the first product to use the knowledge gained through this research. Learn more about the Wisdom Panel and this new study at http://www.wisdompanel.com.

About Mars Veterinary(TM)

Mars Veterinary(TM) is the one of the newest divisions at MARS(R) Incorporated, a company known for innovative consumer and pet food brands that are trusted by people around the world.

Mars Veterinary(TM) is developing sophisticated genetic tests to allow pet owners, veterinarians and care providers to gain insight into the genetic make up of their individual dog. It is reaching new frontiers in canine genomic science, discovering important genetic markers that will help identify breed mixes. These major scientific advances can allow veterinarians and owners to care for dogs with unprecedented wisdom. Through research into pet genetics, Mars Veterinary(TM) is dedicated to revolutionizing personalized pet care strengthening the bond between people and their canine companions.

About Mars(R) Incorporated

MARS(R), Incorporated, is a privately-held family owned company that produces some of the world's leading confectionery, food, petcare, beverage, and health & nutrition products, and operates in more than 65 countries. Mars, Incorporated employs more than 9,000 associates in the United States and 40,000 associates worldwide with research teams located around the world.


'/>"/>
SOURCE Mars Veterinary
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. In a Year of Unprecedented Growth for Biotechnology Innovation, Targeted Therapies Gain Most Significant Traction, According to New Deloitte Study
2. Naviscans PEM Flex(TM) Detects Smallest Cancers Better Compared to MRI in an Independent Study
3. Angiotechs corporate partner, Cook Medical, announces positive interim results for its Zilver(R) PTX(TM) clinical study
4. Cardium Launches New AWARE Clinical Study Website
5. New Study by BioTrends Highlights Practice Management Shifts Among European Nephrologists
6. Peregrine Pharmaceuticals Presents Promising Phase I Data at ASCO and Provides Clinical Update on Its Phase II Bavituximab Breast Cancer Study
7. Clarification on Press Release Issued Earlier Today: Targeted Genetics Confirms Positive, Interim Phase 1/2 Study Findings
8. Genmab Initiates Zalutumumab Combination Study in Colorectal Cancer
9. Global Study Reveals Differences in Standard of Care for Osteoporosis Across the World
10. New Patient Satisfaction Study With budesonide/formoterol Combination Therapy and fluticasone/salmeterol Combination Therapy in Adults With Asthma
11. Sangart, Inc. Completes Enrollment in Second Phase III Study of Hemospan, a Novel Oxygen Transport Agent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... June 23, 2016 On Wednesday, June ... 4,833.32, down 0.22%; the Dow Jones Industrial Average edged 0.27% ... at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the ... Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. ... BIND ). Learn more about these stocks by ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
Breaking Biology Technology:
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/19/2016)... 20, 2016 The new GEZE ... compact web-based "all-in-one" system solution for all door components. ... or the door interface with integration authorization management system, ... systems. The minimal dimensions of the access control and ... building installations offer considerable freedom of design with regard ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
Breaking Biology News(10 mins):