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DNA Software, Inc. Awarded $2.5 M in NIH Funding to Develop Pioneering Nucleic Acid-based Technologies
Date:7/22/2009

ding of the mechanism of the vast majority of known nucleic acid sequences. Half of all clinically used antibiotics target bacterial ribosomes, which are RNA-based molecules. Yet, the 3D structures for the complete ribosomes of many pathogenic bacteria are still unknown. Thus, the ribosome represents an important target for structural prediction and future drug development, including antibiotics for pathogenic bacteria that have developed drug resistance.

DNA Software has a breakthrough technology, called Nucleic Acid CADTM (NA-CADTM), which expands nucleic acid sequence information into all-atom 3D structure predictions of diverse RNA-based structures with near-crystal structure accuracy. With this NIH project, DNA Software is modeling ribosome structure and function and aims to predict the 3D structures of complete ribosomes of clinically relevant pathogens.

Novel Software for Modeling PCR Reaction Rates and Diagnostics with Modified Nucleotides

While current software programs can model the thermodynamics (i.e. the results at equilibrium after a long time) of DNA and RNA reactions, none can model the kinetics (i.e. how fast the reaction takes place). In addition, most software can only model DNA or RNA. None can accurately model the large variety of modified nucleotides that are added to or replace DNA and RNA sequences to increase the sensitivity and specificity of nucleic acid-based diagnostic tests and therapeutics. DNA Software is combining the unique features of kinetics and modified nucleotides with its existing OMP™ (Oligonucleotide Modeling Platform™) software to create a first-rate tool to develop ultra-fast, sensitive, and selective diagnostics. OMP™ has become the gold standard for assay development. It is utilized by prominent research organizations from around the world and across many industries (e.g. biotech, pharmaceutical, diagnostics, biodefense, reagents, government, academic, and institutes)
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