Navigation Links
DNA Predicts Reaction to Drug That Fights Alcohol Dependence
Date:2/7/2008

MUSC researcher heads study, finds patients with gene variant drink less

CHARLESTON, S.C., Feb. 7 /PRNewswire/ -- Inherited genetic makeup often plays a role in determining the risk level for certain diseases, including alcoholism. Now new evidence-based research also shows a correlation between genotyping and the treatment of alcohol dependence.

Investigators participating in the National Institute on Alcohol Abuse and Alcoholism's 2001-2004 Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence Study (COMBINE Study) have discovered a direct correlation between patients with the Asp40 allele, a variation of the receptor gene OPRM1, and the drug naltrexone. Patients with this variant gene responded positively to the drug that blocks opiate receptors in the brain thereby reducing gratification from alcohol. Not only did patients who were treated with naltrexone and have the Asp40 gene variant go without harmful drinking for a longer period of time, but they also consumed fewer beverages on the days they did drink.

"For the first time we might have a 'personalized medical treatment' for alcoholism," said Raymond Anton, M.D., COMBINE Study principal investigator and director of the Center for Drug and Alcohol Programs at the Medical University of South Carolina (MUSC). "Discovery that a common genetic trait predicts treatment response to a commonly used medication should enhance its effectiveness and helps focus alcohol treatment in a cost-effective manner."

These findings provide a viable solution for the 15 to 25 percent of the population that carry the Asp40 allele. Alcohol counseling did not have the same affect as the drug, therefore researchers conclude genotyping is most beneficial without the therapy.

Gene variant carriers of all ethnicities who took naltrexone were more likely than their counterparts to have a good clinical result. However, since the study had more Caucasian participants, the results for this group are the most reliable.

About MUSC

Founded in 1824 in Charleston, The Medical University of South Carolina is the oldest medical school in the South. Today, MUSC continues the tradition of excellence in education, research, and patient care. MUSC educates and trains more than 3,000 students and residents, and has nearly 10,000 employees, including 1,300 faculty members. As the largest non-federal employer in Charleston, the university and its affiliates have collective annual budgets in excess of $1.3 billion. MUSC operates a 600-bed medical center, which includes a nationally recognized Children's Hospital and a leading Institute of Psychiatry. For more information on academic information or clinical services, visit http://www.musc.edu or http://www.muschealth.com.


'/>"/>
SOURCE Medical University of South Carolina
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Multigene Test Predicts Who Could Avoid Chemotherapy Despite Positive Lymph Nodes in Early Breast Cancer
2. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
(Date:6/23/2016)... ... , ... STACS DNA Inc., the sample tracking software company, today announced that ... joined STACS DNA as a Field Application Specialist. , “I am thrilled that ... of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings ...
Breaking Biology Technology:
(Date:6/2/2016)... , June 2, 2016 ... Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & Other ... provider visiongain offers comprehensive analysis of the ... this market will generate revenues of $17.98 billion in ... acquired DVTEL Inc, a leader in software and hardware ...
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
Breaking Biology News(10 mins):