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Cytopia Letter to Progen Shareholders
Date:2/25/2009

.

Yours faithfully

Robert Watson - Chairman Andrew Macdonald - Chief Executive Officer

Where to get more information

www.cytopia.com.au/announcements09.html

www.avexa.com.au

www.progen.com.au

Nasdaq Shareholders

Shareholders who own PGL shares through the Nasdaq and have not received a proxy form are encouraged to contact Gavan Flower directly for assistance.

About Cytopia

Cytopia Ltd is an Australian biotechnology company focused on the discovery and development of new drugs to treat cancer and other diseases. Cytopia conducts its research and drug development through subsidiaries based in Melbourne, Australia and San Francisco, USA and specializes in developing new small molecule compounds with an improved therapeutic profile for the treatment of cancer.

The company's lead drug candidate is CYT997, a vascular disrupting agent (VDA) for the treatment of various cancers, which is currently being trialed in Phase I and Phase II clinical studies. Cytopia is continuing to build on its range of JAK inhibitors and kinase expertise, with CYT387, a novel oral JAK2 inhibitor focused on the treatment of myeloproliferative disorders, expected to enter Phase I clinical studies in 2009.

Website: www.cytopia.com.au

Notes

Resolution 3 is conditional on Resolution 1 being passed, and in any case, limits the share buy-back to $20 million. As the current board does not intend to support a share buyback without the Avexa merger, we recommend you vote against this resolution.

If you have already appoi
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SOURCE Cytopia Limited
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