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Cytogenetics - Technologies, Markets and Companies
Date:1/3/2012

>The Cancer Genome Atlas 113

Concluding remarks on cancer cytogenetics 113

10. Cytogenetics Markets 115

Introduction 115

Methods for study of cytogenetic markets 115

Cytogenetic markets according to technologies 115

Market for FISH technologies 116

Array CGH markets 116

Sorting the markets of overlapping technologies 117

Markets for cytogenetics according to therapeutic areas 117

Geographical distribution of markets for cytogenetics 119

SWOT of competing technologies 119

Unfulfilled needs 120

Limitations of current technologies 122

Promising future developments in cytogenetics 122

Commercial aspects of genome sequencing technologies 122

Cost of genotyping 122

11. Companies 125

Profiles of companies 125

Collaborations 209

12. References 213

Tables

Table 1-1: Historical landmarks in the evolution of cytogenetics 13

Table 2-1: A classification of technologies used for cytogenetics 25

Table 3-1: Classification and scope of FISH and related technologies 32

Table 3-2: A selection of companies with FISH diagnostics 41

Table 4-1: Microarray/biochip-based technologies for cytogenetics 43

Table 4-2: Chromosomal structural abnormalities detected by CGH 46

Table 4-3: Companies developing whole genome chips/microarrays 51

Table 5-1: Companies involved in developing molecular imaging 57

Table 5-2: Technologies for single molecule detection 58

Table 6-1: Nanobiotechnologies for single molecule detection 68

Table 7-1: Types of cancer biomarkers relevant to cytogenetics 74

Table 8-1: Applications of cytogenetics 77

Table 8-2: Application of preimplantation cytogenetic diagnosis in monogenic disorders 86

Table 9-1: WHO classification of myelodysplastic syndromes 103

Table 9-2: Fusion genes in in malignant bone and soft tissue tumors 105
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