Navigation Links
Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology
Date:6/26/2008

ZURICH, Switzerland, June 26 /PRNewswire/ -- The rights to key patents for an innovative screening tool for treatments for cystic fibrosis were transferred today to Swiss biotech company Axentis Pharma AG. The company has acquired the rights from an Austrian firm that has made a vital contribution to the development of new approaches to treating the disease. The core element of the platform technology involves human proteins which - despite offering sufficient functionality - are subjected to enzymatic digestion in untreated cells due to genetic mutations in their structure.

Axentis Pharma AG (Switzerland) today announced that, as part of its takeover of an Austrian research company, it has also acquired two patent families that incorporate a series of international patent applications. The company is taking over these rights from Austrian-based BioDevelops Pharma GmbH, which three years ago identified the therapeutic potential offered by a new approach to the treatment of cystic fibrosis and secured the relevant rights.

The technology directly targets the functional cause of cystic fibrosis - the process whereby the body destroys mutated proteins which were originally designed to regulate the concentration of salt in the epithelial cells of the lungs and other organs. In patients with cystic fibrosis, a genetic defect means that many such proteins are produced with minor structural mutations. Although the mutated proteins still offer sufficient functionality, they are eliminated by quality control functions in the endoplasmic reticulum of the cells. The therapeutic approach now under development at Axentis Pharma enables these proteins - which are still functional despite their mutated structures - to escape enzymatic digestion.

Dr. Gergely Lukacs who guided the experimental set-up in his labs at the Sick Kids Hospital in Toronto explains: "In patients with cystic fibrosis, the protein CFTR (cystic fibrosis conductance regulator) with mutated structure is marked with ubiquitin. These ubiquitin-marked proteins are degraded by multiple mechanisms prematurely. If this marker is missing, the protein evades destruction and can regulate the concentration of water and salt secretion in the lung despite its minor structural defect.

Joerg Zielasek, president of Axentis Pharma AG, comments on what the acquisition of these rights means for the company: "Just six months ago, we reached agreement with aRigen Pharmaceuticals, Japan, on terms and conditions regarding an exclusive license for developing and marketing a patented system for the liposomal encapsulation of an active ingredient designed to combat lung infections in patients with cystic fibrosis. By acquiring the rights to BioDevelops' technology platform, Axentis Pharma is both enhancing its development pipeline and offering both patients and investors extensive prospects for the treatment of this disease."

About cystic fibrosis

Cystic fibrosis is the most common life-threatening hereditary disease among Caucasian population. The disease is caused by a mutation in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications represent the most serious manifestation of the disease - and the reason for the high mortality rate amongst patients. Such complications often involve infection of the bronchi by the bacteria Pseudomonas aeruginosa. Chronic inflammations then cause lung functions to become blocked. Besides the break-down of lung tissue, this also leads to bronchiectasis and lung failure.

About Axentis Pharma AG (http://www.axentispharma.com)

Axentis Pharma AG is a Swiss biotechnology company. The company is using a patent-pending platform technology to develop therapies for diseases caused by incorrect protein folding in the endoplasmic reticulum. The most prominent example of such diseases is cystic fibrosis (mucoviscidosis). The company is in final preparation to initiate a phase II clinical trial using tobramycin liposome formulation against lung infections in Cystic Fibrosis patients.

About the patent families

The inventions which have now been acquired by Axentis Pharma describe the use of molecules for the enzymatic removal of ubiquitin markers in incorrectly folded proteins. The inventions also protect the use of the proteasome inhibitor Bortezomib (Velcade (R)) for second medical use in cystic fibrosis (Velcade (R) has already been approved for use in humans to treat other indications).

For further information, please contact:

Axentis Pharma AG

Leuholz 14

8855 Wangen

Switzerland

T +41-44-817-7817

F +41-44-817-7818

E board@axentispharma.com

Copy Editing & Distribution:

PR&D - Public Relations for Research & Education

Campus Vienna Biocenter 2

1030 Vienna

Austria

T +43-1-505-70-44

E contact@prd.at


'/>"/>
SOURCE Axentis Pharma AG
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Cystic Fibrosis Trial In Children Returns Positive Data
2. Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients
3. Genetic manipulation might model cystic fibrosis
4. Mpex Candidate, MP-376, Granted U.S. Orphan Drug Status for the Treatment of Cystic Fibrosis
5. Data show a decline in cystic fibrosis since introduction of prenatal carrier screening
6. Cystic Fibrosis: License Agreement Boosts Development of Therapy Against Lung Infections
7. PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis
8. GeneGo and the Cystic Fibrosis Foundation Collaborate to Advance Understanding of Cystic Fibrosis
9. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
10. Coalition for Pulmonary Fibrosis and American Thoracic Society Continue Research Partnership Through 2010
11. Wyeth Pharmaceuticals Announces Organizational Change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2016)... ... May 19, 2016 , ... KCAS Bioanalytical and Biomarker Services, ... Director, Large Molecule & Biomarker Bioanalysis. , Dr. Siddiqui has more than 15 ... for preclinical and clinical safety programs. “We’ve seen significant demand for, and we ...
(Date:5/18/2016)... 2016 The Biotech industry continues to ... that there are no opportunities ahead. Today, ActiveWallSt.com has on ... THLD ), Seattle Genetics Inc. (NASDAQ: SGEN ... Corp. (NASDAQ: OPHT ). Sign up now to ... http://www.activewallst.com/ Threshold Pharmaceuticals Inc.,s shares gained ...
(Date:5/17/2016)... -- Haselmeier announces the launch by Merck ... EMA, the European Medicines Agency. Originally launched in 2011 ... new pen version includes enhancements to further improve the ... patients during use. Its enhanced design has ... with a larger display window that improves the readability ...
(Date:5/17/2016)... BASEL, Switzerland , May 17, 2016 /PRNewswire/ ... sciences company located in Basel, Switzerland ... an investigational oral inhibitor of P38 mitogen-activated protein ... ) , Strekin will build the ... Pamapimod in indications in which MAP Kinases play ...
Breaking Biology Technology:
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
Breaking Biology News(10 mins):