Navigation Links
Cyntellect Launches CellXpress(TM) System to Boost Productivity of Biopharmaceutical Process Development

Accelerated cloning of high-efficiency production cell lines may get new protein therapeutics to the clinic sooner and reduce production costs

SAN DIEGO, Sept. 22 /PRNewswire/ -- Cyntellect, a privately-held life sciences company leading the development and commercialization of live-cell analysis and manipulation systems, announced today the launch of CellXpress, powered by the Company's proprietary laser-based system LEAP(TM). The automated system brings new improvements in speed, cost and optimal clone selection for cell line development. Biopharmaceutical teams developing manufacturing cell lines for potential medicines can now reduce the time required to get to clinical testing, decrease production costs of protein therapeutics and substantially increase the number of development projects which can be processed in parallel.

CellXpress can be purchased by customers directly from Cyntellect in the U.S. and Europe and from Cyntellect's distribution partner, Summit Pharmaceuticals, in Japan.

The CellXpress system exploits high-speed imaging of living cells combined with simultaneous laser elimination of undesired cells, leaving behind cells that are efficiently secreting biopharmaceutical proteins. The process is initiated by imaging thousands of cells per well to quantify the level of protein being secreted by each cell. This unique measurement is enabled by Cyntellect's proprietary in situ assay for capturing and labeling secreted protein around living individual cells. The best secreting cell is located in seconds within a pool of thousands of candidate cells, and once located; all other undesired cells are selectively eliminated with the laser leaving behind only the best cell. This purification results in a verified clone that is very likely to generate a highly secreting cell lines. The imaging and purification processes can be repeated hundreds of times an hour to enable scanning through millions of cells per day, often yielding hundreds of highly-secreting clones. In contrast, current manual and semi-automated approaches are able to screen through thousands of cells per day and often yield tens of clones following many weeks of growth and assessment.
The CellXpress system can provide significant benefits to customers by:

-- Yielding verified highly-secreting single-cell clones in less than 24

hours (vs. weeks)

-- Isolating ten-fold more highly secreting clones than traditional


-- Selecting optimal clones based on real-time assessment of secretion,

growth and stability

-- Reducing time to confirmed highly-secreting clones by more than 50%

-- Delivering up to 90% reduction in labor and material costs

-- Enabling processing of multiple projects / cell lines in parallel

"The increasing pressures on bioprocess development teams to improve manufacturing productivity and shorten timelines have not been adequately addressed," said Fred Koller, Ph.D., Cyntellect's President and Chief Executive Officer. "Our goal with CellXpress is to provide a reliable, scalable and efficient product that customers can purchase and use in-house to empower significant productivity gains, while also helping get new potential drugs to market sooner."

Previously, CellXpress was available only as a fee for service from SAFC Biosciences. Now, customers can purchase the technology as a product directly from Cyntellect and its distributors allowing bioprocessing teams to harvest the productivity benefits of CellXpress as part of their in-house programs.

About Cyntellect

Cyntellect, Inc. is a life sciences company committed to revolutionizing the use of living cells in life science research and cellular therapy. The Company combines expertise in high-speed cell imaging and laser-based manipulation to develop products that enable novel cell imaging, purification, and transfection capabilities to enhance the productivity of laboratory research, recombinant protein production, high-content cellular assays, functional genomics and proteomics, and cell purification, including processing of cells for therapeutic transplantation. For additional information please visit the Company's web site at

SOURCE Cyntellect
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Cyntellect to Collaborate With the Burnham Institute for Medical Research
2. Histogen Launches BioNuesis, the Only All-Human Stem Cell Culturing Kit
3. Sigma-Aldrich Launches Breakthrough Genome-Editing Tools
4. Lena Chow, Veteran Biotech Marketer, Launches New Website
5. BioSpace Launches Life Science Career Content and Resources from the Biotech Work Portal
6. Sinovac Launches Seasonal Influenza Vaccine Anflu(R) for 2008-2009 Flu Season
7. Caliper Launches Small Animal Molecular Imaging System Enabling Real-Time Video Observation
8. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
9. Familybuilder Launches the Familybuilder Global Network at DEMOfall 08
10. SearchMedica Launches Practice Management Search Engine for Medical Professionals
11. BIOLOCK(TM) USA Launches Affordable Fingerprint door Locks for Homes and Offices
Post Your Comments:
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris ... that its business and prospects remain fundamentally strong ... Zoptrex™ (zoptarelin doxorubicin) recently received DSMB recommendation to ... completion following review of the final interim efficacy ... 2 Primary Endpoint in men with heavily pretreated ...
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( ), ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
(Date:11/24/2015)... PA (PRWEB) , ... November 24, 2015 , ... This ... entrepreneurs at competitive events in five states to develop and pitch their BIG ideas ... projects from each state are competing for votes to win the title of SAP's ...
Breaking Biology Technology:
(Date:11/19/2015)... NEW YORK , Nov. 19, 2015  Although ... the market is dominated by a few companies, according ... Qiagen. These companies own 51% of the market share of ... report, The World Market for Molecular Diagnostic ... "The market is still controlled by one ...
(Date:11/17/2015)... 2015  Vigilant Solutions announces today that Mr. ... Directors. --> --> ... the partnership at TPG Capital, one of the largest ... Billion in revenue.  He founded and led TPG,s Operating ... companies, from 1997 to 2013.  In his first role, ...
(Date:11/12/2015)... 11, 2015   Growing need for low-cost, ... has been paving the way for use of ... discrete analytes in clinical, agricultural, environmental, food and ... used in medical applications, however, their adoption is ... to continuous emphasis on improving product quality and ...
Breaking Biology News(10 mins):