Accelerated cloning of high-efficiency production cell lines may get new protein therapeutics to the clinic sooner and reduce production costs
SAN DIEGO, Sept. 22 /PRNewswire/ -- Cyntellect, a privately-held life sciences company leading the development and commercialization of live-cell analysis and manipulation systems, announced today the launch of CellXpress, powered by the Company's proprietary laser-based system LEAP(TM). The automated system brings new improvements in speed, cost and optimal clone selection for cell line development. Biopharmaceutical teams developing manufacturing cell lines for potential medicines can now reduce the time required to get to clinical testing, decrease production costs of protein therapeutics and substantially increase the number of development projects which can be processed in parallel.
CellXpress can be purchased by customers directly from Cyntellect in the U.S. and Europe and from Cyntellect's distribution partner, Summit Pharmaceuticals, in Japan.
The CellXpress system exploits high-speed imaging of living cells
combined with simultaneous laser elimination of undesired cells, leaving
behind cells that are efficiently secreting biopharmaceutical proteins. The
process is initiated by imaging thousands of cells per well to quantify the
level of protein being secreted by each cell. This unique measurement is
enabled by Cyntellect's proprietary in situ assay for capturing and
labeling secreted protein around living individual cells. The best
secreting cell is located in seconds within a pool of thousands of
candidate cells, and once located; all other undesired cells are
selectively eliminated with the laser leaving behind only the best cell.
This purification results in a verified clone that is very likely to
generate a highly secreting cell lines. The imaging and purification
processes can be repeated hundreds of times an hour to enable scanning
through millions of cells per day, often yielding hundreds of
highly-secreting clones. In contrast, current manual and semi-automated
approaches are able to screen through thousands of cells per day and often
yield tens of clones following many weeks of growth and assessment.
The CellXpress system can provide significant benefits to customers by:
-- Yielding verified highly-secreting single-cell clones in less than 24
hours (vs. weeks)
-- Isolating ten-fold more highly secreting clones than traditional
-- Selecting optimal clones based on real-time assessment of secretion,
growth and stability
-- Reducing time to confirmed highly-secreting clones by more than 50%
-- Delivering up to 90% reduction in labor and material costs
-- Enabling processing of multiple projects / cell lines in parallel
"The increasing pressures on bioprocess development teams to improve manufacturing productivity and shorten timelines have not been adequately addressed," said Fred Koller, Ph.D., Cyntellect's President and Chief Executive Officer. "Our goal with CellXpress is to provide a reliable, scalable and efficient product that customers can purchase and use in-house to empower significant productivity gains, while also helping get new potential drugs to market sooner."
Previously, CellXpress was available only as a fee for service from SAFC Biosciences. Now, customers can purchase the technology as a product directly from Cyntellect and its distributors allowing bioprocessing teams to harvest the productivity benefits of CellXpress as part of their in-house programs.
Cyntellect, Inc. is a life sciences company committed to revolutionizing the use of living cells in life science research and cellular therapy. The Company combines expertise in high-speed cell imaging and laser-based manipulation to develop products that enable novel cell imaging, purification, and transfection capabilities to enhance the productivity of laboratory research, recombinant protein production, high-content cellular assays, functional genomics and proteomics, and cell purification, including processing of cells for therapeutic transplantation. For additional information please visit the Company's web site at http://www.cyntellect.com.
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