Navigation Links
Currently approved drugs found effective in laboratory mice against bioterror threats
Date:4/11/2013

ial agents, but the researchers did not identify any non-antibiotic compounds with broad spectrum antibacterial activity.

Lomefloxacin and erythromycin were found to be the most potent compounds in protecting mice against anthrax. Lomeflaxacin is used to treat bronchitis and urinary tract infections. Erythromycin is used against respiratory tract infections.

The most noteworthy antiviral compound identified was chloroquine which disrupted virus entry and replication in cells of two or more viruses in vitro and protected mice against Ebolavirus.

Due to the demanding complexity of working with these agents under laboratory conditions as well as the fact that human drug clinical trials cannot be ethically conducted for any of these agents, conventional drug discovery and development approaches are particularly challenging. For these agents, the FDA must evaluate the efficacy of drugs on the basis of their activities in appropriate animal models, under agency guidance. Thus, drug-repurposing offers many advantages, particularly given the fact that human safety studies have already been conducted.

Members of the Texas Biomed team are presently pursuing whether the other drugs could be equally useful for treatment of these viruses.

"It would be important to determine if a combination of drugs could be more potent than each individual drug," Davey said. "Such synergy, when seen, usually means you can lower the dose of each drug and still have a big impact on the disease while minimizing bad side effects. Such work could prove useful as an easy frontline defense against these viruses."


'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology technology :

1. iBio, Inc. Receives Notice from NYSE MKT Staff that Company Currently is Below Certain Continued Listing Standards
2. Tri-Valley Dentist Dr. Endre Selmeczy Currently Features Oral Sedation Dentistry
3. Upsher-Smith Currently Recruiting People With Epilepsy To Evaluate Investigational Rescue Treatment For Seizure Clusters
4. Indoor Air Quality Professionals Provide New Expert Witness Services To Help Mold Victims Get Mold Claims Approved and Win in Court, AGCEnvironmental Explains How
5. Cardiometabolic Health Congress Expert Faculty Evaluate the Clinical Implications of Newly FDA-Approved Treatment for Homozygous Familial Hypercholesterolemia
6. Recently FDA-Approved Full Neck Treatment for Sagging Skin Now Available at Maryland Laser Skin and Vein Institute
7. Pinnaclife Animal Health Features Seal N Heal Wound Shield in New Veterinary Dermatologist Tested and Approved Product Line!
8. K-V Pharmaceutical Use of Cash Collateral Approved by U. S. Bankruptcy Court
9. K-V Pharmaceutical "First Day" Motions Approved by U.S. Bankruptcy Court
10. SpermCheck® Fertility, the Only FDA Approved At-Home Screening Test for Men to Determine Normal or Low Sperm Count, Now Available to Couples Planning or Struggling to Conceive
11. Intravenous Remodulin Approved for the Treatment of Pulmonary Arterial Hypertension in Most of the European Union
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... Air Force Office of Scientific Research grant to examine ... that will provide clues for predicting fatigue in aircraft ... said the new technology and process would be better ... wing., "We,ll be able to determine metal fatigue at ... this scale," Huang said. "Certain patterns of surface roughness ...
(Date:10/17/2014)... HILDEN, Germany , October 17, ... , Translational research in cancer and other diseases ... the American Society of Human Genetics annual meeting ... linked to Ingenuity ®  Knowledge Base greatly exceeds ... Ingenuity ®  Variant Analysis™ adds fully ...
(Date:10/17/2014)... 2014 Bioquell, provider of germ-eliminating ... health facilities around the world to decontaminate locations ... Among the many places the hydrogen peroxide vapor ... Hospital Dallas and at the National Institutes of ... have been utilized to decontaminate patient rooms, equipment, ...
(Date:10/17/2014)... The global SWIR market report defines and ... of revenue. This market is valued at $60.1 million ... by 2019, at a CAGR of 10.2% from 2014 ... global SWIR market report, to get an idea of ... of the segmentation of the market, and is supported ...
Breaking Biology Technology:UT Arlington project to detect possible damages in aircraft parts early in process 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6The global SWIR market is expected to reach $97.9 million by 2019 - New Report by MicroMarket Monitor 2The global SWIR market is expected to reach $97.9 million by 2019 - New Report by MicroMarket Monitor 3
... 2011 Trimble (NASDAQ: TRMB ) announced ... safety solutions, has integrated the ThingMagic® Astra® UHF Reader ... the patient experience and significantly assists in the goal ... a safer and more inviting medical experience. Most recently, ...
... solar cells, industrial catalysts and video displays are among ... chemically distinct sides. These particles are named after the ... allow them to form novel structures and new materials. ... particles down to a few nanometers in diameter ...
... carbon-based material that could revolutionize the way solar power ... transparent conductor made of carbon nanotubes provides an ... reliant on a relatively rare mineral. Due to ... potential to boost the long-term viability of solar power ...
Cached Biology Technology:XECAN and Trimble Partner to Deliver ThingMagic Powered RFID Oncology Solution 2XECAN and Trimble Partner to Deliver ThingMagic Powered RFID Oncology Solution 3XECAN and Trimble Partner to Deliver ThingMagic Powered RFID Oncology Solution 4XECAN and Trimble Partner to Deliver ThingMagic Powered RFID Oncology Solution 5New technique maps twin faces of smallest Janus nanoparticles 2Researchers use carbon nanotubes to make solar cells affordable, flexible 2
(Date:10/14/2014)... cancer tumors scavenge and hoard copper that is an ... be a fatal weakness. , Researchers at Duke ... cells by delivering a trove of copper along with ... with the mineral, leaving non-cancer cells healthy. , The ... for other uses, could soon be tested in clinical ...
(Date:10/14/2014)... house fly genome for the first time, revealing robust ... that thrives in pathogen-rich dung piles and garbage heaps. ... Genome Biology , will increase understanding of house ... adapt to resist insecticides, which could lead to novel ... and transmit more than 100 human and animal diseases, ...
(Date:10/14/2014)... doses of fish oil supplements, rich in omega-3 fatty acids, ... heartbeat in which the heart can beat as fast as ... led by the Montreal Heart Institute were published in the ... October 7th. , For the trial, 337 patients with atrial ... 4 grams of fish oil a day or to placebo ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2House fly genome reveals expanded immune system 2
... viable future biofuel especially if harvested in summer. ... could provide an important alternative to terrestrial grown biofuels; ... a seasonal basis. Harvesting the kelp in July when ... sugar release for biofuel production. , "The storage carbohydrate ...
... the RIKEN Brain Science Institute (BSI) and their ... a little-studied amyloid peptide in promoting Alzheimer,s disease ... is more abundant, more neurotoxic, and exhibits a ... in earlier research, suggesting a potential role in ...
... which could have practical applications for the medical industry. ... self-cleaning sticky surfaces, which could be useful for a ... medical bandages, tyre performance, and even long lasting adhesives," ... who will be presenting this work at the Society ...
Cached Biology News:Biofuels from the sea 2Overlooked peptide reveals clues to causes of Alzheimer's disease 2Frog feet could solve a sticky problem 2
Agar, 500 g. Noble Agar.Moisture: < 10%, ash: < 1.6%, EEO (-mr): < 0.450 (pH 8.4). Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Ms anti-Cyclophilin D...
... qualitatively detect EGFR gene ... (FFPE) tissue sections, metaphase ... preparations, using Chromogenic In ... In Situ Hybridization (FISH) ...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
Biology Products: