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CryoLife Receives Humanitarian Use Device Designation for SynerGraft(R) Processed Human Aortic Heart Valves
Date:10/6/2009

.S. market it would address, and the Company's plans and timing for applying and obtaining an HDE. These forward looking statements may not occur as, when or to the extent expected, and are subject to a number of risks, including the following: CryoValve SG aortic human heart valve continues to undergo testing, and additional test results may not yield the anticipated benefits. Many factors impact the suitability of patients for transplants, and there can be no guarantee that CryoLife will receive an HDE designation. Doctors may not continue to accept SynerGraft products for use in treating their patients, and additional SynerGraft products in development may not achieve anticipated benefits or approvals. The Company does not undertake to update its forward-looking statements. Additional risks and uncertainties impacting CryoLife's business are detailed in CryoLife's Securities and Exchange Commission filings, including CryoLife's Form 10-K filing for the year ended December 31, 2008, our Form 10-Q for the quarter ended March 31, 2009, our Form 10-Q for the quarter ended June 30, 2009, and the Company's other SEC filings. The Company does not undertake to update its forward-looking statements.

For additional information about the company, visit CryoLife's Web site:

http://www.cryolife.com

    Media Contacts:

    D. Ashley Lee
    Executive Vice President, Chief Financial
    Officer and Chief Operating Officer
    Phone: 770-419-3355

    Dana Hartline
    Vice President
    Edelman
    Phone: 404-262-3000

SOURCE CryoLife, Inc.


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SOURCE CryoLife, Inc.
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4. CryoLife Announces Implants of First FDA-Cleared SynerGraft(R) Processed Human Cardiac Patch Material
5. CryoLife Receives FDA 510(k) Clearance for SynerGraft(R) Processed Human Cardiac Patch Material
6. CryoLife Reports Record First Quarter Revenues of $26.7 Million
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8. CryoLife to Present at Sidotis 13th Annual New York Emerging Growth Institutional Forum
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10. CryoLife Announces Release Date and Teleconference Call Details for 2008 Fourth Quarter and Year End Financial Results
11. CryoLife, Inc. Receives Tissue From 100,000th Donor, Marking Industry Milestone
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