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Crescendo Biologics Announces First 'Triple Knockout' Mouse
Date:9/29/2010

istics of antibody platforms - human origin and in vivo maturation - to allow rapid creation of high affinity fragments. The company intends to progress at least one VH-based product to the clinic.

Crescendo is now working to generate mice that combine its newly developed YAC and the triple knockout mouse, in order to generate a first generation Crescendo mouse platform. In addition, Crescendo is generating additional YAC transgenics to progress towards the best in class mouse.

About Crescendo Biologics Ltd

Crescendo Biologics will apply highly innovative antibody fragment technologies to the development of new targeted therapeutics. The Crescendo transgenic mouse platform under development has the potential to rapidly and predictably generate high-affinity human heavy chain antibodies that readily yield VH fragments that have no requirement for humanisation. This is combined with a powerful in vitro ribosome display technology which offers significant advantages over existing approaches in antibody optimisation. VH fragments provide great flexibility as a starting point for the development of new targeted therapeutics combining the specificity and binding affinity of antibodies with certain desirable characteristics of small molecules.

Crescendo's technologies were invented by scientists at the Babraham Institute, Cambridge (UK). The Company has raised GBP4.5 million in seed funding from leading life sciences investors, Sofinnova Partners with Aitua, Avlar BioVentures and the Rainbow Seed Fund also participating. http://www.crescendobiologics.com

Contacts Mike Romanos/Amanda Bettison Crescendo Biologics Tel: +44-(0)1223-497140 Email: mromanos/abettison@crescendobiologics.com Chris Gardner Citigate Dewe Rogerson Tel: +44-(0)207-638-9571 Email: chris.gardner@citigatedr.co
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SOURCE Crescendo Biologics Ltd
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