Navigation Links
Creating Functional Hepatic Tissue in a Bioengineered Human Liver
Date:10/30/2010

BOSTON, Oct. 30 /PRNewswire/ -- Researchers at Wake Forest University Baptist Medical Center's Institute for Regenerative Medicine demonstrated the generation of a bioengineered human liver organoid using a liver bioscaffold made from an intact liver extracellular matrix, and filled (seeded) with primary human liver progenitor and endothelial cells.

The ability to generate a liver scaffold and preserve its vascular network had been demonstrated previously. These studies showed the possibility of seeding these bioscaffolds with liver cells from animals, but the possibility of generating functional human hepatic tissue was still in question.

The current study demonstrated that human liver cells can be seeded through the portal vein of the liver bioscaffold, and can be maintained in a specialized bioreactor with constant culture medium perfusion up to one week. Progressive human liver tissue formation was documented, as well as liver-associated functions. Widespread cell proliferation inside the bioengineered liver tissue with low cell apoptosis was also observed.

According to Pedro Baptista, PharmD, PhD, "These studies provide the basis to begin transplantation of bioengineered livers in small animal models. We believe that this functional hepatic tissue, once transplanted, will maintain and further gain function as it progressively grows and develops in vivo. Also, the exclusive use of human cells opens new horizons for drug testing and toxicology studies. This will more closely mimic drug metabolism in the human liver, which animal models can, at times, be extremely difficult to predict."

"This technology may provide a new approach for liver bioengineering, enabling the use of organ scaffolds with human cells to produce functional human liver tissue," said Dr. Baptista.

The researcher hails this as a new approach to whole organ liver bioengineering that might prove to be critical for drug discovery and treatment of liver disease. "This laboratory-generated hepatic tissue offers great potential as a drug discovery and toxicology testing platform. Moreover, we believe that further translation into larger animal species opens the door for the generation of transplantable bioengineered human livers that can help patients with end-stage chronic liver disease who are waiting for a donor."

Abstract title:

The Use of Whole Organ Decellularization for the Bioengineering of a Human Vascularized Liver

About the AASLD

AASLD is the leading medical organization for advancing the science and practice of hepatology. Founded by physicians in 1950, AASLD's vision is to prevent and cure liver diseases. This year's Liver Meeting®, held in Boston, Massachusetts, October 29-November 2, will bring together more than 7,500 researchers from 55 countries.

A pressroom will be available from October 30 at the annual meeting. For copies of abstracts and press releases, or to arrange for pre-conference research interviews contact Gregory Bologna at 703-299-9766. To pre-register, call Ann Haran at 703-299-9766.

Press releases and all abstracts are available online at www.aasld.org. Media Contact: Gregory Bologna703/299-9766gbologna@aasld.org Press Room: October 30 – November 2, 2010Hynes Convention Center, Room 208Telephone: 617-954-3106Researchers: Pedro Baptista, PharmD, PhD; Shay Soker, PhDEmail: pbaptist@wfubmc.edu; ssoker@wfubmc.edu  Phone: 336-713-1325This release was issued through The Xpress Press News Service, merging e-mail and satellite distribution technologies to reach business analysts and media outlets worldwide. For more information, visit http://www.XpressPress.com.


'/>"/>
SOURCE American Association for the Study of Liver Diseases (AASLD)
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose
2. Axela Acquires Xceed Molecular Creating Powerhouse in Robust and Easy-to-Use Systems for Translational Medicine
3. Researchers develop ultra-simple method for creating nanoscale gold coatings
4. Inspired by a cotton candy machine, engineers put a new spin on creating tiny nanofibers
5. Synthetic Genomics Inc. Applauds the Venter Institutes Work in Creating the First Synthetic Bacterial Cell
6. Creating a Better Health Ecosystem Focus of Presentation by Aleres Dr. Gordon Norman at Population Health & Disease Management Colloquium
7. A Recovery Act Success Story: NIH Funding of Biomedical Innovation Is Creating Jobs, Fueling Industry Growth, and Helping Reduce Long-term Health Care Costs
8. Technique for Creating Authentic Rat Embryonic Stem Cells Published in Cell
9. Cleveland Clinic Recognizes New Strategies for Creating Vaccines for Avian Flu as a Top Ten Medical Innovation for 2009
10. Nuvelo and ARCA biopharma Announce Merger Agreement Creating Late-Stage Cardiovascular Biotechnology Company
11. Creating unconventional metals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/7/2019)... ... January 07, 2019 , ... Kainos ... its Parkinson's Disease drug candidate, code-named "KM-819." KM-819 is an orally active ... took place in South Korea. , This Phase 1 randomized, double-blind, placebo-controlled ...
(Date:1/4/2019)... ... January 03, 2019 , ... Calidi Biotherapeutics, Inc., ... today announced the founding of a scientific and medical advisory board (SMAB). The ... leaders in the Immuno-Oncology field. The founding members of Calidi Biotherapeutics SMAB include ...
(Date:12/18/2018)... ... 17, 2018 , ... ABCT , the Accelerator for ... to participate in the annual program. Twelve ventures will participate in the 6.5-month-long ... network. All startups receive an entrepreneur coach, access to active business professionals and ...
(Date:12/13/2018)... ... December 11, 2018 , ... ... and nurses can use to quickly detect Clostridium difficile (C. diff), a dangerous ... of a handheld device that can be used onsite in doctor’s offices and ...
Breaking Biology Technology:
(Date:12/13/2018)... ... 13, 2018 , ... Biocompare, the leading online information resource ... Need to Know about Antibody Manufacturing” . This educational resource is the third ... this film is to educate scientists about antibody production, validation, and responsible sourcing. ...
(Date:12/6/2018)... ... , ... Stewart has been on the business side of ... During his recent five-year tenure with InSphero he was the US General Manger ... in Brunswick, Maine. Through these experiences, Stewart has a deep understanding of the ...
(Date:12/5/2018)... ... December 03, 2018 , ... uBiome, the leader in microbial ... the Division of Gastroenterology and Hepatology at UC San Diego and staff gastroenterologist ... the board of leading scientists and doctors from around the world, Dr. Zarrinpar ...
Breaking Biology News(10 mins):