Navigation Links
Course correction needed for Alzheimer's therapies, experts warn
Date:1/26/2011

biomarkers substances in the body that point to a disease to identify patients before they show the symptoms associated with Alzheimer's. With biomarkers, it may be possible to test Alzheimer's drugs in pre-symptomatic volunteers.

"The dilemma is, can you treat people as if they have Alzheimer's if they do not?" said Koo, co-director of the Shiley-Marcos Alzheimer's Disease Research Center at UC San Diego. "That's the catch-22."

Most proposed Alzheimer's disease therapies target so-called "brain plaques" proteins that clog the spaces between brain cells. Experimental models suggest that therapies targeting these proteins, known as amyloid beta-peptide, may be effective.

Approximately 90 experimental therapies intended to slow or stop the progression of the disease are under way, many of them targeting Alzheimer's hallmark brain plaques, according to the Alzheimer's Association. The problem is the strategies are likely to be much less effective when tested in patients who are already experiencing confusion, memory loss or personality changes.

But simply placing more emphasis on prevention has its own complications, the researchers say. To date, no drug candidates have been found to be effective at prevention or suitably safe enough for a patient to take for a lifetime.

And even if such a drug were found, clinical testing would take well more than a decade and cost pharmaceutical companies millions of dollars. If the drug were successful and there is no guarantee the company's patent would expire before it had a chance to recover its expenses.

"It is important to find ways to ensure that the commercial sector will invest in prevention trials that may take 10 years or more to complete," Koo said.

The authors said they are not the first to point out misalignment between clinical and preclinical studies, or summarize current therapeutics, or critique how trials are conducted.

But by presenting
'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Bunker Hill Community College Wins Major Endorsement for Biotechnology Courses
2. Hospital Marketplace E-Course Suite Adds Insight on Quality and Information Systems
3. Saunders Solutions for Vets Professional Skills Online-course Suite Wins a Prestigious 2010 Brandon Hall Excellence in Learning Award
4. Atrium Innovations Announces Commencement of a First Normal Course Issuer Bid
5. Simbionix Relocates its Courseware Business to its Corporate Headquarters in Cleveland, Ohio
6. Stratford Career Institute Announces New Veterinary Assistant Course
7. Summit Dental Institute Offers A Hands-On One-Day Imtec MDI Mini Dental Implant Certification Course For Dentists
8. The Wound Institute(R) Launches Educational Course on Bacterial Biofilms
9. University of Maryland School of Pharmacy Adopts BioSoteria's eLearning Drug Safety Courses
10. RAPS Partners With Chinese University to Develop Regulatory Courses
11. The International Food Protection Training Institute (IFPTI) Announces 2010 Course Schedule
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... D.C., September 30, 2014 Applying a well-known ... researchers at Harvard University has demonstrated the ability ... -- work that holds promise for making future, ... detailing the sides of next-gen rocket ships and ... light passes through oil in water, it becomes ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released the DSES-1000 long-travel ... for measuring displacement in rubber and other soft ... distance, the DSES-1000 can measure elongations up to ... mm. In addition, it achieves +/- 0.2 percent ... +/- 100 µm below 50-mm stroke. , The ...
(Date:9/30/2014)... , Sept. 30, 2014  RegeneRx Biopharmaceuticals, Inc. ... that it has received a Canadian Patent for ... Peptides.  This patent includes claims using thymosin beta ... actin-sequestering peptides for these purposes.  The patent will ... Biopharmaceuticals, Inc. ( www.regenerx.com ) ...
(Date:9/30/2014)... 2014  KemPharm, Inc., a clinical-stage specialty pharmaceutical ... proprietary new molecular entity (NME) prodrugs, announced today ... (USPTO) issued U.S. Patent No. 8,816,083 to KemPharm ... Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of ... The patent, which extends through 2032, ...
Breaking Biology Technology:Taking thin films to the extreme 2Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2
... ARBOR, Mich., July 13 Accuri Cytometers, Inc. today ... financing. The financing included current investors Fidelity Biosciences, ... well as the InvestMichigan! Program co-managed by Credit Suisse. ... D financing to provide additional working and growth capital ...
... ... Pharmaceutical Production Executive to Head its Two U.S. Contract Manufacturing Facilities , ... Hackensack, NJ (Vocus) July 13, ... Daryl LeSueur as Vice President of Manufacturing Operations. As head of Manufacturing ...
... advantage in the media. A new study by Dr. ... the journal of Israel,s National Security College, describes how ... too. "Information warfare" plays a crucial ... so than conventional weapons. Therefore, the information warfare against ...
Cached Biology Technology:Accuri Cytometers Completes $4 Million Series D Financing 2Accuri Cytometers Completes $4 Million Series D Financing 3Accuri Cytometers Completes $4 Million Series D Financing 4Accuri Cytometers Completes $4 Million Series D Financing 5Progenitor Cell Therapy Appoints VP of Manufacturing Operations 2Progenitor Cell Therapy Appoints VP of Manufacturing Operations 3Information warfare in the 21st century: Ideas are sometimes stronger than bombs 2
(Date:9/30/2014)... . , Animals ... such as exposure to predators. Researchers from the Max ... study on different populations of great tits that risk-taking ... High metabolic rates and low temperatures were associated with ... more likely to approach potential predators. , The readiness ...
(Date:9/29/2014)... , coupled with a high-fat diet, may cause animals to ... mBio , the online open-access journal of the American Society ... Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that mice ... weight when fed a high-fat diet. Mice that did not ... consuming a high-fat diet, and mice that had C. ...
(Date:9/29/2014)... pizza in school? According to a new Food and ... chef-made meals can increase participation in the National School ... consumption of vegetables by 16%! , Chefs Move to ... campaign, pairs chefs with schools in order to provide ... school food service workers. , A CMTS event was ...
Breaking Biology News(10 mins):Risky metabolism 2Gut bacteria promote obesity in mice 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... Scientists have found that a large proportion of infants ... disease. The disease is the most prevalent acute wheezing ... admission to hospital in the first year of life in ... admitted to hospital for bronchiolitis - needing oxygen and help ...
... from small rings of naturally occurring plant DNA can ... embryonic plants where they are expressed, duplicated as plant ... -- a long-term goal for those interested in improving ... issue of PLoS-Genetics, a team of academic and commercial ...
... Research Hospital have identified the cell that gives rise to ... growth and development. The finding suggests for the first time ... induce fully developed neurons to multiply and coax the injured ... work appears in the Oct. 19 issue of the journal ...
Cached Biology News:Scientists find predisposition to bronchiolitis in some babies 2Transgenics transformed 2Transgenics transformed 3St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory 2St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory 3
... Deletion Machine is based on the simple, ... by Goryshin and Reznikoff, and by York ... of deletions and inversions by intramolecular transposition ... plasmid vector. Although most researchers will be ...
... I provides reagents and a protein standard for ... agents and detergents. The RC DC protein assay ... and standards sufficient for 500 standard assays: 250 ... II, 250 ml alkaline copper tartrate solution, 2 ...
... crystalline solid. PROTECT FROM LIGHT. Useful in cell activation ... Purity: ≥98% by TLC. Soluble in DMSO or ... a 10 mM stock in DMSO is recommended. Microliter ... 2 O with rapid mixing (e.g. 10 μl into ...
... Both compact and lightweight, the Moticam ... microscope through the eyepiece, eyetube, or trinocular ... easy to use Plug-and-Play Images 2.0ML software ... Image manipulation tools to maximize resolution for ...
Biology Products: