Navigation Links
CorMatrix Announces Pre-Clinical Data Suggesting Next Generation ECM Technology(TM) Can Improve Cardiac Function
Date:11/10/2008

- Data presented at American Heart Association Annual Scientific Sessions -

NEW ORLEANS, Nov. 10 /PRNewswire/ -- CorMatrix Cardiovascular, Inc., an Atlanta-based company dedicated to developing and delivering unique extracellular matrix (ECM(TM)) biomaterial devices that harness the body's innate ability to repair damaged cardiovascular tissue, presented data today demonstrating that an injection of an emulsified version of their ECM Technology(TM) improved cardiac function.

The study tested the hypothesis that an injection of ECM emulsion into infarcted myocardium would promote wound healing and angiogenesis by naturally recruiting c-kit positive cells. The study involved rats that were subjected to 45 minutes of coronary occlusion, followed by three, seven, 21 and 42 days of reperfusion with and without the ECM emulsion injection, respectively.

"Reinforcing our earlier findings, the subjects that received the emulsified ECM injection over an extended period showed significant reversal of cardiac damage and improvement in overall function following the induced occlusion," said Robert G. Matheny, M.D., Chief Scientific Officer. "The improved heart function we observed at 42 days is consistent with prior data and further demonstrates the technology's promise and sustainability," added Matheny.

At seven days post reperfusion, the population of c-kit positive cells within the emulsion area increased significantly compared to the control (32+/-0.6 vs. 15+/-3/1000 nuclei) and myofibroblasts accumulated in the emulsion region to a significant extent (59+/-8 vs. 30+/-3/HPF). Angiogenesis in the emulsion area was significantly enhanced, evidenced by increased density value of a-SMA-positive vessels (70+/-10 vs. 20+/-4/HPF) and vWF-positive vessels (95+/-14 vs. 34+/-8/HPF). At 42 days post reperfusion, echocardiography showed improvements in end-systolic volume (0.3+/-0.1 vs. 0.6+/-0.3 ml), fractional shortening (33+/-5 vs. 24+/-6) and ejection fraction (67+/-6 vs. 53+/-10) in the emulsion group. The wall thickness of the infarcted middle anterior septum was also significantly greater in the emulsion group (0.19+/-0.02 vs. 0.15+/-0.02 cm).

"We are committed to conducting ongoing pre-clinical research as we help to further increase physicians' awareness and understanding of the significant role that extracellular matrix materials can have in cardiac applications," commented Beecher Lewis, President and Chief Operating Officer of CorMatrix Cardiovascular. "We will continue pre-clinical trials with our next generation ECM Technology(TM) product and look forward to eventually moving to clinical trials to determine its ability to ultimately reverse the effects of heart failure in humans."

The use of extracellular matrix technology in non-cardiovascular applications has established a significant foothold in soft tissue repair, wound management and orthopedic applications. Since the launch of CorMatrix's ECM for Pericardial Closure, the technology has been used at more than 220 hospitals across the U.S. and has been implanted in more than 9,000 cardiac procedures.

"We have received a tremendous response from the clinical community for our products for pericardial closure and for cardiac tissue repair," said Lewis. "With our next generation ECM Technology, we are pleased to be leading the way toward another important advancement for cardiac surgeons and their patients."

About CorMatrix ECM Technology(TM)

CorMatrix Cardiovascular holds an exclusive license from Purdue University to research, develop, manufacture and market naturally occurring ECM products for cardiovascular applications. The company currently has U.S. FDA clearance and European approval with a CE Mark to market its ECM Technology as an implant for pericardial closure, FDA clearance in the U.S. for cardiac tissue repair, and is conducting pre-clinical studies on a number of cardiovascular applications including an emulsified, injectible form of its ECM Technology as a potential treatment for heart failure.

About CorMatrix Cardiovascular, Inc.

CorMatrix Cardiovascular, a privately held company based in Atlanta, Georgia, is dedicated to developing and delivering innovative biomaterial devices that harness the body's own innate ability to regenerate damaged heart tissue. For more information visit http://www.cormatrix.com.


'/>"/>
SOURCE CorMatrix Cardiovascular, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. CorMatrix Cardiovascular to Present Data on Its Next Generation ECM Technology(TM) at Annual Transcatheter Cardiovascular Therapeutics (TCT) Conference in Washington, D.C.
2. CorMatrix(R) Announces FDA 510(k) for Novel Biomaterial Implant for Intracardiac Repair
3. Amylin Pharmaceuticals Announces Strategic Restructuring and Workforce Reduction
4. 3SBio Inc. Announces Third Quarter 2008 Results
5. Sangamo BioSciences Announces Results From Diabetic Neuropathy Clinical Trial SB-509-601
6. China Medicine Announces Conference Call to Discuss Third Quarter 2008 Results
7. GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update
8. Medical Simulation Corporation Announces Partnership With University of South Florida
9. Amgen Foundation Announces $2.5 Million Expansion of Amgen Scholars Program to Europe
10. Genomic Health Announces Publication of a Study Demonstrating the Oncotype DX(R) Breast Cancer Assay Influences Chemotherapy Treatment Recommendation in 44 Percent of Patients Evaluated
11. Synvista Therapeutics Announces Availability of Haptoglobin Genotyping Technology at The Annual Scientific Sessions of the American Heart Association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , ... March 21, 2017 , ... ... , more than tripling its goal and raising over $30,000 in the first ... that grows nutritious veggies & herbs fast, easy, and affordably, anywhere. , “Simply ...
(Date:3/22/2017)... Washington, USA, and CARDIFF, UK (PRWEB) , ... March 21, 2017 ... ... regional blood flow and tissue oxygenation, is being explored as a way to track ... near-infrared spectroscopy study on tonic pain activation by cold pressor test ,” published today ...
(Date:3/22/2017)... HACKENSACK, N.J. and PETACH TIKVAH, ... Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult ... Chaim Lebovits , Chief Executive Officer, will provide ... at Sachs Associates 2 nd Annual Neuroscience Biopartnering ... at the New York Academy of Sciences. ...
(Date:3/22/2017)... SAN FRANCISCO , March 22, 2017 /PRNewswire/ ... the fastest growing genetic information companies, today announced ... the diagnosis of Spinal Muscular Atrophy (SMA) ... the leading lethal genetic disorders among infants as ... disease in childhood. The new test, announced during ...
Breaking Biology Technology:
(Date:2/8/2017)...  Aware, Inc. (NASDAQ: AWRE ), a leading ... for its quarter and year ended December 31, 2016. ... $3.9 million compared to $6.9 million in the same quarter ... was $0.6 million compared to $2.6 million in the fourth ... 2016 was $0.5 million, or $0.02 per diluted share, which ...
(Date:2/8/2017)... The biometrics market has reached a ... organizations, desires to better authenticate or identify users ... challenge questions), biometrics is quickly working its way ... is driven by use cases, though there traditionally ... uses cases, with consumer-facing use cases encompassing authentication, ...
(Date:2/7/2017)... , Feb. 7, 2017   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... , its innovative, highly flexible and award winning eClinical ... customers. iMedNet is a proven Software-as-a-Service (SaaS) ... Data Capture (EDC), but also delivers an entire suite ...
Breaking Biology News(10 mins):