Navigation Links
Consortium publishes Phase II map of human genetic variation
Date:10/17/2007

results have opened up new avenues of research, taking us to places we had not imagined in our search for better ways to diagnose, treat and prevent disease.

The second-generation haplotype map, or Phase II HapMap, contains more than 3.1 million genetic variants, called single nucleotide polymorphisms (SNPs) three times more than the approximately 1 million SNPs contained in the initial version. The more SNPs that are on the map, the more precisely researchers can focus their hunts for genetic variants involved in disease. The rapid growth of genome-wide association studies over the past year and half has been fueled by the HapMap consortiums decision to make its SNP datasets immediately available in public databases, even before the first and the second versions of the map were fully completed.

Researchers around the globe have now associated more than 60 common DNA variants with risk of disease or related traits, with most of the findings coming in the past nine months. As just one example, the Wellcome Trust consortium in England looked at 14,000 cases and 3,000 shared controls, finding variants associated with increased risk of bipolar disorder, coronary artery disease, Crohn's disease, rheumatoid arthritis, type 1 diabetes and type 2 diabetes.

We are thrilled that the worldwide scientific community is taking advantage of this powerful new tool and we anticipate even more exciting findings in the future. The improved SNP coverage offered by the Phase II HapMap, along with better statistical methods, promises to further increase the accuracy and reliability of genome-wide association studies, said Gil McVean, Ph.D., of the University of Oxford in England, who co-led the group that analyzed the HapMap data.

Another analysis leader, Mark Daly, Ph.D., of Massachusetts General Hospital and the Broad Institute of MIT and Harvard in Cambridge, Mass., said, "In addition to providing a critical backbone for standard genome-wide as
'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology technology :

1. Research consortium aims to bring security and defense contracts to Wisconsin
2. Wisconsin consortium aims for defense business
3. Doyle announces biobased energy consortium
4. E-business consortium evaluates 12 desktop search engines
5. University Consortium Enables Transformation and Survival for Wisconsin Businesses
6. Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock Gel-Heavy
7. Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock Gel-Heavy
8. Easy preparation of total RNA from cultured cells with TRIzol and Eppendorf Phase Lock Gel
9. Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000
10. Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... help in the fight against terrorism with the creation ... explosives with the use of light and special glass ... Actuators B: Chemical , the researchers describe a novel ... as low as 6.3 ppm (parts per million). It ... , "Traditionally explosives detection has involved looking for metals ...
(Date:7/10/2014)... Hall effect in bilayer graphene and shown that this ... electric field. , The fractional quantum Hall effect, ... are exposed to large magnetic fields, is a striking ... behave as a single system. However, while the basic ... of this collective behavior remain not well understood, in ...
(Date:7/10/2014)... the University of Illinois at Urbana-Champaign provides new ... of spin and heat at the nanoscale, and ... for data storage and information processing. , ... momentum. In a typical charge current, electrons, spin-angular-momentum ... explained David Cahill, a professor of materials science ...
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... Sept. 28 Idenix,Pharmaceuticals, Inc. (Nasdaq: ... discovery and development of drugs for the ... strategic restructuring. As part of the,restructuring, Idenix ... AG related to Tyzeka(R)/Sebivo(R). Per the amended ...
... the innovator and leader of BioZ(R) Impedance Cardiography ... clearance from,the U.S. Food and Drug Administration (FDA) ... (EMR) interface capability for its BioZ Dx,System. The ... partnership between,the Company and Philips Medical Systems that ...
... Class Action Settlement, NORCROSS, Ga., Sept. ... the global leader in providing automated instrument-reagent,systems ... that the,Securities and Exchange Commission (SEC) has ... investigation into certain,activities involving the company,s Italian ...
Cached Biology Technology:Idenix Pharmaceuticals Restructures to Concentrate Efforts on HCV and HIV Programs 2Idenix Pharmaceuticals Restructures to Concentrate Efforts on HCV and HIV Programs 3Idenix Pharmaceuticals Restructures to Concentrate Efforts on HCV and HIV Programs 4CardioDynamics Receives FDA 510(k) Clearance for Innovative Clinical Parameters and Electronic Medical Record Compatibility 2CardioDynamics Receives FDA 510(k) Clearance for Innovative Clinical Parameters and Electronic Medical Record Compatibility 3Immucor Settles SEC Investigation 2
(Date:7/10/2014)... , July 7, 2014 Fingerprint Cards, ... major design win (DW). A Chinese Top 5 smartphone OEM ... start of mass production in October 2014.   ... Top 5 smartphone OEM, which has a planned date for ... target sales volume for this phone of 3 million units. ...
(Date:7/10/2014)... , July 9, 2014 The widespread ... in large part by meaningful use and related ... providers interact with laboratory information. Now, more than ... field of clinical informatics in order to deliver ... To address the educational needs of pathologists in ...
(Date:7/10/2014)... or soap might not be ape friendly, and the situation ... in the Cell Press journal Current Biology on ... already led to the conversion of Southeast Asian forest into ... guidelines are not put in place very soon, researchers say ... Africa will be bad news for great apes there as ...
Breaking Biology News(10 mins):FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4Hunger for vegetable oil means trouble for Africa's great apes 2
... Award of the American Association for the Advancement of ... "for his transformative impact and contributions towards the production ... sciences." Tchounwou, associate dean of graduate studies and ... Technology at Jackson State University in Jackson, Miss., will ...
... have sustained farming villages in the arid southwestern United ... runoff and social and economic factors that favor modernism ... results reflect similar changes around the world, where once ... provide benefits of modern living but also the uncertainties ...
... of a symposium on Saturday, February 15, at the 2014 Annual ... Chicago. The session, which features two members of Congress and ... place 10:00-11:30 a.m. CST in Grand Ballroom B of the Hyatt ... of the Golden Goose Award will be announced. ...
Cached Biology News:2013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University 22013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University 3Dartmouth study shows US Southwest irrigation system facing decline after 4 centuries 2
Mouse monoclonal to Casein Kinase 2 beta ( Abpromise for all tested applications). entrezGeneID: 1460 SwissProtID: P13862...
Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP). [Source:Uniprot/SWISSPROT;Acc:P08697] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
... monoclonal [HDAC8-48] to HDAC8 Regulation ... several mechanisms such as DNA methylation, ... modifications of histones, which include the ... groups of lysine residues present in ...
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
Biology Products: