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Congresso ESH 2013, dallo studio SEVITENSION nuove evidenze sull'efficacia della combinazione fissa olmesartan/amlodipina vs. perindopril/amlodipina nel controllo della pressione arteriosa centrale
Date:6/25/2013

olmesartan e di 10 mg di amlodipina per valutare se questa fosse in grado di abbassare la pressione arteriosa centrale a un livello simile a quello ottenuto con la somministrazione di 8 mg di perindopril e di 10 mg di amlodipina, valutata nello studio CAFE'. I risultati mostrano che non solo questo obiettivo è stato raggiunto, ma che la combinazione olmesartan/amlodipina abbassa la pressione arteriosa centrale in misura maggiore rispetto alla combinazione con perindopril. Tale risultato è stato confermato anche con altre modalità di misurazione, compresa quella brachiale standard e quella ambulatoria nelle 24 ore. L'altra evidenza scientifica emersa dallo studio riguarda il fatto che il 75,6 % dei pazienti trattati con la combinazione olmesartan/amlodipina sono stati in grado di "normalizzare" la loro pressione arteriosa a livelli più bassi di 140/90 mmHg, cioè lo standard raccomandato dalla Società Europea di Ipertensione. La proporzione dei pazienti che hanno ottenuto lo stesso livello di pressione arteriosa con la somministrazione della combinazione con perindopril é stata invece più bassa di quasi il 20% (57,5 %).

"Dalla pubblicazione dello studio CAFÉ, la combinazione di 8 mg di perindopril con 10 mg di amlodipina è stata considerata lo standard ideale. Questo standard è stato comparato con l'associazione di 40 mg di olmesartan e 10 mg di amlodipina, che è riuscito ad abbassare i livelli della pressione arteriosa centrale in modo più significativo. Migliore è la risposta della pressione arteriosa, minori sono i rischi di sviluppare eventi cardiovascolari", ha concluso Ruilope.

Olmesartan+Amlodipina

  • Olmesartan è un antagonista recettoriale dell'angiotensina II. L'angiotensina II svolge fisiologicamente m
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SOURCE Daiichi Sankyo Europe GmbH
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