Navigation Links
Computer predicts anti-cancer molecules
Date:6/16/2008

A new computer-based method of analyzing cellular activity has correctly predicted the anti-tumour activity of several molecules. Research published today in BioMed Central's open access journal Molecular Cancer describes 'CoMet' a tool that studies the integrated machinery of the cell and predicts those components that will have an effect on cancer.

Jeffrey Skolnick, in collaboration with John McDonald, led a team from the Georgia Institute of Technology who have developed this new strategy. As Skolnick explains, "This opens up the possibility of novel therapeutics for cancer and develops our understanding of why such metabolites work. CoMet provides a deeper understanding of the molecular mechanisms of cancer".

The small molecules that are naturally produced in cells are called metabolites. Enzymes, the biological catalysts that produce and consume these metabolites are created according to a cell's genetic blueprints. Importantly, however, the metabolites can also affect the expression of genes. According to the authors "By comparing the gene expression levels of cancer cells relative to normal cells and converting that information into the enzymes that produce metabolites, CoMet predicts metabolites that have lower concentrations in cancer relative to normal cells".

The research proves that by adding such putatively depleted metabolites to cancer cells, they exhibit anticancer properties. In this case, growth of leukemia cells was slowed by all nine of the metabolites suggested by CoMet. The future for this treatment looks bright, in McDonald's words, "While we have only performed cell proliferation assays, it is reasonable to speculate that some metabolites may also exhibit many other anticancer properties. These could be important steps on the road to a cure".


'/>"/>

Contact: Charlotte Webber
charlotte.webber@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1

Related biology technology :

1. Microsoft scientist highlights urgent need for new computer models to address climate change
2. Carbon nanoribbons could make smaller, speedier computer chips
3. Researchers bring new meaning to the term computer bug
4. Hybrid computer materials may lead to faster, cheaper technology
5. iCAD, Inc. Awarded Two Additional Patents for Its Computer-Aided Detection Technology
6. Growing tiny carbon nanotube wires to connect computer chips of the future
7. Using supercomputers to make safer nuclear reactors
8. Nanotube forests grown on silicon chips for future computers, electronics
9. Penn engineers design computer memory in nanoscale form that retrieves data 1,000 times faster
10. Penn engineers design computer memory in nanoscale form that retrieves data 1,000 times faster
11. FluForecast(R) Replikin Count(TM) Predicts That the H5N1 Cycle Which Began in 1996 Is Now Over
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... Diego, CA (PRWEB) , ... August 15, 2017 ... ... company pioneering graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces the launch ... the number of steps needed to gain kinetic binding data for a wide ...
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea ... various biotic and abiotic factors. During this educational webinar, participants will learn about ... well as gain a better understanding of how genomics is important for coffee ...
(Date:8/11/2017)... 11, 2017  Market researcher Kalorama Information ... article regarding the telemedicine market.  The telemedicine ... Information.  The article, "Heart and Asthma ...  used information from Kalorama Information,s Remote Patient ... Market  (Sleep, Diabetes, Vital Signs /EKG ...
(Date:8/10/2017)... Philadelphia, PA (PRWEB) , ... August 09, 2017 ... ... back to the classroom next week-- as students. From August 14th through the ... Institute. The institute, which debuted in the summer of 2016, provides Philadelphia-based middle ...
Breaking Biology Technology:
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
Breaking Biology News(10 mins):