Navigation Links
Columbia University researchers use nanoscale transistors to study single-molecule interactions
Date:1/24/2011

New York January 23, 2011 An interdisciplinary team from Columbia University that includes electrical engineers from Columbia's Engineering School, together with researchers from the University's departments of Physics and Chemistry, has figured out a way to study single-molecule interactions on very short time scales using nanoscale transistors. In a paper to be published online January 23 in Nature Nanotechnology, they show how, for the first time, transistors can be used to detect the binding of the two halves of the DNA double helix with the DNA tethered to the transistor sensor. The transistors directly detect and amplify the charge of these single biomolecules.

Prior to this work, scientists have largely used fluorescence techniques to look at interactions at the level of single molecules. These studies have yielded fundamental understanding of folding, assembly, dynamics, and function of proteins and other cellular machinery. But these techniques require that the target molecules being studied be labeled with fluorescent reporter molecules, and the bandwidths for detection are limited by the time required to collect the very small number of photons emitted by these reporters.

The Columbia researchers, including Professor of Electrical Engineering Ken Shepard, Professor of Chemistry Colin Nuckolls, and graduate students Sebastian Sorgenfrei and Chien-Yang Chiu, realized that transistors, like those used in modern integrated circuits, have reached the same nanoscale dimensions as single molecules. "So this raised the interesting question," said Sorgenfrei, the lead author on the study, "as to whether these very small transistors could be used to study individual molecules."

They have discovered that the answer is "yes." The transistors employed in this study are fashioned from carbon nanotubes, which are cylindrical tubes made entirely of carbon atoms. While these are still emerging devices for electronics applicat
'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
212-854-3206
Columbia University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. OncoGenex Pharmaceuticals Named Life Sciences Company of the Year by LifeSciences British Columbia
2. Leading North American Emergency Medical Services Provider British Columbia Ambulance Service Selects NICE Inform for Improved Service
3. Columbia engineering team discovers graphenes weakness
4. NIH Funds $1M Research at Quest Product Development and University of Colorado for New Digitally-Controlled Endoscopes
5. University of Pennsylvania scientists move optical computing closer to reality
6. RainDance Technologies Signs a Collaboration Agreement with sanofi-aventis and Louis Pasteur University to Launch dScreen Consortium within ALSACE BIOVALLEY cluster
7. University of Southern California Receives Cancer Diagnosis System for Detecting Esophageal Dysplasia
8. Stem Cell Transplantation Program at Hackensack University Medical Center: First in Nation to Receive Joint Commission Certification for Quality and First in New Jersey to be Named a Blue Distinction(R) Center for Specialty Care.
9. [video] Ronald Andrews, CEO of Clarient, Inc. Discusses Agreement With University of Pennsylvania School of Medicine on WallSt.nets 3-Minute Press Show
10. George Washington University Hospital Purchases Orthocrats TraumaCad(TM) for Orthopedic Preoperative Planning
11. Sigma-Aldrich and the University of Illinois Offer New Boronic Acid Surrogates to Researchers Worldwide Through Licensing Agreement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
(Date:12/25/2014)... 2014 The report “Service Quality Management ... & Provider Type - Global Advancements, Worldwide Forecasts & ... in-depth analysis and forecasting of revenues. , Browse ... pages and in-depth TOC on “Service Quality Management (SQM) ...
(Date:12/24/2014)... and NEW YORK , Dec. 24, 2014 ... advancing patient care in critical areas, announced the closing of ... and warrants to purchase up to an aggregate 3,500,000 shares ... share and $.01 per warrant.  The warrants have a per ...
(Date:12/24/2014)... 2014   BioLife Solutions , Inc. (NASDAQ: BLFS ... grade hypothermic storage and cryopreservation freeze ... and tissues  ("BioLife" or the "Company"), today announced that it ... 4, 2015 (the "Annual Meeting"). Because the expected ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... Biopharmaceuticals Ltd. (Nasdaq: XTLB , TASE: XTL) today ... regarding the Company,s activities in seeking to acquire potential assets ... XTL. The Company is currently evaluating several merger proposals that ... companies who operate in and outside of the healthcare space. ...
... 23andMe , Inc., an industry leader in ... research company dedicated to the development of treatments for ... in Davos, Switzerland, that they are collaborating to advance ... of the companies to the World Economic Forum, where ...
... dots created by researchers at Canada,s National Institute for ... new level of control over individual electrons, a development ... Composed of a single atom of silicon and measuring ... smallest quantum dots ever created. , Quantum ...
Cached Biology Technology:XTL Biopharmaceuticals Provides Update on Potential Strategic Alternatives 223andMe and mondoBIOTECH Partner to Advance Research of Rare Diseases 223andMe and mondoBIOTECH Partner to Advance Research of Rare Diseases 3Smallest ever quantum dots bring real world applications closer 2
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... addition of the "The Global Watermarking and ... http://photos.prnewswire.com/prnh/20130307/600769 ... digital media watermarking and fingerprinting markets. Watermarking aims ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
(Date:12/17/2014)...  HITLAB SM announced today its completion of a ... to current U.S. Food and Drug Administration (FDA) regulations. ... and smart phone application trials utilizing the highest principles ... is determined to improve global healthcare access, quality, and ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... by the Biotechnology and Biological Sciences Research Council and ... have developed a revolutionary way of capturing a high-resolution ... technology that is attractive for science, industry and consumer ... in standard cameras and digital movie projectors they have ...
... Feb. 12, 2010 -- By taking advantage of a ... for electronics designers, a team led by Oak Ridge ... biological sensor with unprecedented sensitivity. Ultimately, researchers believe ... approaches the theoretical limit, surpassing other state-of-the-art chemical sensors. ...
... Haven, Conn.Yale University scientists have streamlined the process for synthesizing ... and other diseased cells, and have found that they represent ... this week,s online edition of the Journal of the ... family of compounds known as the kinamycins, which are naturally ...
Cached Biology News:Cameras of the future: heart researchers create revolutionary photographic technique 2Cameras of the future: heart researchers create revolutionary photographic technique 3Cameras of the future: heart researchers create revolutionary photographic technique 4New ORNL sensor exploits traditional weakness of nano devices 2Scientists synthesize unique family of anti-cancer compounds 2
Rabbit Polyclonal antibody to Perilipin Applications: This antibody is useful for Western blot anlaysis where a band at ~60 kDa is seen....
... A thermostable, thermoactive designer enzyme ... single-tube-reaction. AccuRT RNA PCR enzyme allows ... be performed at elevated temperatures (65C), ... from the template and results in ...
Request Info...
EML1 (K-16)...
Biology Products: