In addition to the Competition being a part of Global Entrepreneurship Week, the Competition finalists also are being given the opportunity to meet with Dr. John Holdren, Assistant to President Obama for Science and Technology and Director of the White House Office of Science and Technology Policy, and Todd Park, the United States Chief Technology Officer. The meeting further emphasizes the importance of the innovative and entrepreneurial endeavors undertaken by this group who have the potential to positively influence and advance the future of our society.
First prize graduate winner Ortac's approach offers a versatile therapeutic strategy based on hiding and protecting otherwise immunogenic non-human enzymes from the immune system and their delivery to the target. He does this by fabricating what he calls "nano-wiffle-balls" out of silica and hiding enzymes within, then enclosing the wiffle balls with a second layer, trapping the enzymes, but leaving holes for other compounds to pass through. A non-toxic substance can be delivered systemically through the body, and activated by the enzymes inside the wiffle balls at the treatment site. In this way, therapy can potentially be applied to the majority of cancers including blood cancers, solid tumors, and metastic lesions with application-specific modifications. The Johns Hopkins first prize undergraduate winners have invented a plier-like device that can drive and transfer a needle across its jaw, intended to provide improved fascia closure during abdominal surgery. With this device, the team hopes that surgeons will be able to close the fibrous tissue layer more easily and safely, allowing for le
|SOURCE National Inventors Hall of Fame|
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