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Cognition Therapeutics Completes $2.5M in Series A1 Financing to Advance Alzheimer's Disease Drug Treatment Program
Date:1/20/2011

ceived positive peer review and has obtained significant grant funding in its early development, and we are delighted to be the syndication lead in this financing round.  Alzheimer's affects 4.5 million people in the United States today, with that number expected to exceed 12 million by 2050."

Funds raised in this round will support preclinical work required for IND candidate selection, and enable Cognition Therapeutics to further exploit novel molecular targets and pathways identified through the company's phenotypic screens.    

"Our drug leads selectively block the activity of the toxic oligomeric form of Abeta protein that interferes with normal learning and memory," said Susan Catalano, Ph.D., Cognition Therapeutics Chief Science Officer.  "Studies from the world's leading academic laboratories indicate that the memory deficits caused by this oligomeric protein are among the earliest changes seen in Alzheimer's and Mild Cognitive Impairment, the precursor to Alzheimer's. These studies indicate that blocking the effects of this protein may halt or reverse Alzheimer's disease."  

Cognition has developed a number of screening strategies to identify small molecules capable of blocking the central toxicity of proteins in Alzheimer's disease and other neurodegenerative diseases. These assays emphasize phenotypic or functional responses of mature primary neurons to the toxic proteins. Cognition's proprietary chemistry platform converts natural product molecular scaffolds into low molecular weight chemically stable drug-like molecules, and is thus a source of novel pharmacophores and valuable drug candidates.

"The registration of the company's proprietary biological screening approach with positive results in an animal model of Alzheimer's disease is a significant achievement," said Dr. Cynthia Lemere, Associate Professor of Neurology at Harvard University's Brigham & Women's Hospital and member of Cognition's
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SOURCE Cognition Therapeutics Inc.
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