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Codexis Licenses New Drug Metabolite Profiling and Lead Diversification Technology From the California Institute of Technology
Date:8/29/2007

body during the break-down (metabolism) of drugs. Primary metabolites are largely formed in the liver by human P450 enzymes to aid in elimination of a drug from the body. In some cases, metabolites can be toxic, while for other drugs, "active" metabolites have shown improved efficacy and lower toxicity than the administered drug substance. The US Food and Drug Administration now recommends metabolic characterization for all new investigational human therapeutics.

Codexis, Inc. is a leading developer of clean biocatalytic process technologies that can substantially reduce the cost of manufacturing across a broad range of industries. Codexis' proprietary directed evolution technologies enable novel solutions for efficient, cost-effective and environmentally friendly processes for pharmaceutical, energy and industrial chemical applications. In 2006, the company was recognized by the U.S. EPA with a Presidential Green Chemistry Challenge Award. Codexis is a registered trademark of Codexis, Inc. For more information please visit http://www.codexis.com

Contact: Justin Jackson, jjackson@burnsmc.com of Burns McClellan, 212-213-0006, or Lyn Christenson, Codexis, lyn.christenson@codexis.com, 650-298-5368.


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