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Clinical Study Findings Show Safety and Procedure Success for TopSpin IntraVascular MRI Catheter for the Coronary Arteries
Date:10/23/2007

tem in patients undergoing cardiac catheterization. The primary endpoint of the study was the incidence of major adverse cardiac events (MACE) at 24 hours. The incidence of MACE at 24 hours was only 0.96% (1 patient), and at 30 days was 1.9% (1 additional patient). There were no deaths and no perforations. Performance success was achieved in 88%, and at least one IVMRI measurement was obtained in 95% of patients.

Rupture of coronary plaque with subsequent thrombus (blood clot) formation is the underlying cause of most acute coronary syndromes (ACS). Early reliable assessment of lipid- rich vulnerable plaques near the surface of the arterial wall may lead to more aggressive treatment of coronary artery disease and reduce the overall incidence of myocardial infarction (heart attack) and death. TopSpin's IVMRI catheter is the first device designed for percutaneous intravascular imaging and characterization of the tissue lipid composition of coronary plaque during a conventional cardiac catheterization procedure. The IVMRI catheter is designed to measure the lipid content within the target plaque.

About TopSpin

TopSpin Medical developed an innovative and unique technology for high-resolution MRI using an IntraVascular MRI (IVMRI) catheter for the coronary arteries, without the need for an expensive and bulky external MRI setup. The catheter contains those components, which are usually found in a conventional MRI scanner, only that they are miniaturized to less than 2 millimeters in size. In 2006 TopSpin Medical began to develop its technology for imaging prostate cancer by an integrated endo-rectal MRI and ultrasound probe.

STATEMENTS IN THIS PRESS RELEASE WHICH ARE NOT HISTORICAL DATA ARE FORWARD-LOOKING STATEMENTS WHICH INVOLVE KNOWN AND UNKNOWN RISKS, UNCERTAINTIES OR OTHER FACTORS NOT UNDER THE COMPANY'S CONTROL, WHICH MAY CAUSE ACTUAL RESULTS, PERFORMANCE OR ACHIEVEMENTS OF THE COMPANY TO BE MATERIALLY DIFFERENT FROM THE RESULTS, PERFORMANCE
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SOURCE TopSpin Medical Israel Ltd
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