Navigation Links
Cleveland Clinic-Led Research Uncovers New Mechanism That Heightens Risk of Heart Disease
Date:9/10/2007

Findings Appear in Sept. 9 Issue of the Journal Nature Medicine

CLEVELAND, Sept. 10 /PRNewswire/ -- Heart disease often hits with devastating effects in people with normal cholesterol levels, yet seemingly misses striking others who smoke, or have multiple risk factors. A new research discovery may help explain why one person suffers a heart attack and yet another doesn't.

Researchers at Cleveland Clinic's Lerner Research Institute have discovered a mechanism that contributes to the hardening of arteries and could explain why some individuals are at greater risk of developing heart disease than others.

In a study published in the Sept. 9 issue of the journal Nature Medicine, researchers identify a mechanism that is found in high-risk populations, including smokers and individuals with chronic kidney disease, as well as the general population, which heightens an individual's risk of developing heart disease. The researchers found that proteins in the bloodstream, when damaged by a process called carbamylation, change the way cells behave, promoting the accumulation of harmful substances in the arteries and raising the risk of heart disease.

"This is a breakthrough in explaining why some populations are at greater risk for developing heart disease," said the study's lead author, Stanley Hazen, M.D., Ph.D., Section Head of Preventive Cardiology at Cleveland Clinic and a researcher in the Lerner Research Institute. "To date, we have focused on cholesterol as the central linchpin of how cardiovascular disease occurs. However, the presence of heart disease in many high-risk groups has not been adequately explained by traditional risk factors, including elevated cholesterol levels. This study highlights a new mechanism that augments an individual's risk of heart disease."

Researchers began their work trying to understand why smokers are at increased risk for developing heart disease. In a study of 1000 patients and additional cell an
'/>"/>

SOURCE Cleveland Clinic
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. The DIG System Nonradioactive Automated High-Throughput In Situ Hybridization: a Powerful Tool for Functional Genomics Research
2. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
3. Control Your siRNA Research
4. Getting Started with MicroRNA Research
5. Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System
6. Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
7. Research Organics
8. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
9. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
10. Research Tools for Analysis of ZAP-70
11. Technical Specifications Accelerating Your Research with the BD FACSCanto High Throughput Sampler Option
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... The Collaborative R&D Terms and ... comprehensive understanding and unprecedented access to the collaborative ... worlds leading life science companies. , The report ... and why companies enter collaborative R&D deals. , ... deals terms provides critical insight into the negotiation ...
(Date:8/31/2014)... (PRWEB) September 01, 2014 Available ... lighting needs for research and cultivation of a ... by Valoya’s proprietary LEDs with proven patented and ... ensures uncompromised light uniformity in critical applications in ... white LEDs. , “Our customers have a large ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 This ... current state of the Epoxy Hardener industry ... basic overview of the industry, including definitions, applications ... Chinese domestic market analysis are provided with a ... of the market. A comparison between the international ...
(Date:8/29/2014)... 2014  Pfenex Inc. (NYSE MKT: PFNX), a ... high-value and difficult to manufacture proteins including biosimilar ... financial results for the second quarter ended June ... of our initial public offering, we have the ... candidates, derived from our proprietary protein expression platform," ...
Breaking Biology Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8
... utilizing targeted direct-mail marketing, Middleton-based Customer Potential ... health care provider unexpected returns: Forty-six patients for ... and $152,944 net profit. CPM is a provider ... ,With advancements in variable digital imaging and predictive ...
... Inc. , a Madison-based provider of managed Internet network ... funding from First Analysis , Argentum Group ... will be used to expand the companys sales and ... ,The demand for managed network security is growing dramatically ...
... in the air and we are emerging into the second week ... and say whether this will be a good or bad year ... significant activities have already taken place that impact the land of ... the last two weeks has approved not one but two new ...
Cached Biology Technology:Biotech 2004: Cautious optimism 2Biotech 2004: Cautious optimism 3
(Date:9/2/2014)... contain essentially the same DNA sequence their genetic ... of cells in the different parts of the body ... same construction master plan, an additional regulatory layer exists ... are active. This mechanism involves modifications of genome-bound histone ... (e.g. methylation). It acts on top of the genetic ...
(Date:9/2/2014)... in the September issue of The FASEB ... strategy to diagnose the leading cause of blindness ... has occurred. This advance involves quantifying the early ... of retinal vessels. Using new probes developed by ... molecular development of diabetic retinopathy. , "My goal ...
(Date:9/2/2014)... 2014 A study published in the September ... American Academy of Child and Adolescent Psychiatry ... psychiatric diagnosis had an increased risk of developing ... Using data from the nationwide Danish registers, a ... Nielsen, Psychiatry, Aalborg University Hospital, Denmark, studied 48,299children ...
Breaking Biology News(10 mins):Throwing a loop to silence gene expression 2Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2Risk of diabetes in children and adolescents exposed to antipsychotics 2
... Engineers like to make things that work. And if ... size of proteins, antibodies, and virusesmimicking the behavior of ... carry an enormous amount of information in a very ... computation and neutral systems, and bioengineering, explains, "I tend ...
... DURHAM, N.H. New research from Plymouth State University ... and bleeding horseshoe crabs for biomedical purposes causes short-term ... the crabs, population decline in parts of the east ... harvests the blue blood from almost half a million ...
... from natural disasters usually means rebuilding infrastructure and reassembling ... heal, too, and scientists are pioneering new methods to ... epicenter of China,s devastating Wenchuan earthquake in 2008 was ... biodiversity hotspot and home to the beloved and endangered ...
Cached Biology News:Building artificial cells will be a noisy business 2Building artificial cells will be a noisy business 3Biomedical bleeding affects horseshoe crab behavior 2Biomedical bleeding affects horseshoe crab behavior 3Gauging what it takes to heal a disaster-ravaged forest 2
...
... Triple-angle light scattering detector for ... digital signal processing hardware for two ... UV detectors. Also contains an analog ... interfacing to strip chart recorders. Includes ...
... The FDSS6000 System is an ... assays, assay development and high throughput ... and luminescence modalities., The Hamamatsu light ... highlight our companys decades-long experience in ...
... Experion StdSens reagents and supplies, ... and supplies sufficient to perform standard-sensitivity ... chips on the Experion automated electrophoresis ... gel, 20 microliters RNA StdSens stain, ...
Biology Products: