| HOME >> BIOLOGY >> TECHNOLOGY |
Findings Appear in Sept. 9 Issue of the Journal Nature Medicine
CLEVELAND, Sept. 10 /PRNewswire/ -- Heart disease often hits with devastating effects in people with normal cholesterol levels, yet seemingly misses striking others who smoke, or have multiple risk factors. A new research discovery may help explain why one person suffers a heart attack and yet another doesn't.
Researchers at Cleveland Clinic's Lerner Research Institute have discovered a mechanism that contributes to the hardening of arteries and could explain why some individuals are at greater risk of developing heart disease than others.
In a study published in the Sept. 9 issue of the journal Nature Medicine, researchers identify a mechanism that is found in high-risk populations, including smokers and individuals with chronic kidney disease, as well as the general population, which heightens an individual's risk of developing heart disease. The researchers found that proteins in the bloodstream, when damaged by a process called carbamylation, change the way cells behave, promoting the accumulation of harmful substances in the arteries and raising the risk of heart disease.
"This is a breakthrough in explaining why some populations are at greater risk for developing heart disease," said the study's lead author, Stanley Hazen, M.D., Ph.D., Section Head of Preventive Cardiology at Cleveland Clinic and a researcher in the Lerner Research Institute. "To date, we have focused on cholesterol as the central linchpin of how cardiovascular disease occurs. However, the presence of heart disease in many high-risk groups has not been adequately explained by traditional risk factors, including elevated cholesterol levels. This study highlights a new mechanism that augments an individual's risk of heart disease."
Researchers began their work trying to understand why smokers are at
increased risk for developing heart disease. In a study of 1000 patients
and additional cell an
'/>"/>
| SOURCE Cleveland Clinic Copyright©2007 PR Newswire. All rights reserved |
Related biology technology :
1. The DIG System Nonradioactive Automated High-Throughput In Situ Hybridization: a Powerful Tool for Functional Genomics Research
2. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
3. Control Your siRNA Research
4. Getting Started with MicroRNA Research
5. Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System
6. Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
7. Research Organics
8. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
9. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
10. Research Tools for Analysis of ZAP-70
11. Technical Specifications Accelerating Your Research with the BD FACSCanto High Throughput Sampler Option
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |