Navigation Links
Circulomics Receives $1.7M to Develop Nanobind Methods for FFPE DNA/RNA Extraction and NGS Library Preparation
Date:10/5/2017

NIH has awarded Circulomics two SBIR grants totaling over $1.7M to develop new applications of its Nanobind DNA/RNA extraction technology. Nanobind is a novel magnetic disk that contains a high density of micro- and nanostructured silica on the surface and that can be used for a wide variety of sample preparation applications. The nanostructured surface provides high capture efficiency, immense binding capacity, and protection from damage. Previous NIH grants have been used to develop kits for high molecular weight DNA extraction from cultured cells, bacteria, blood, and tissues.

The first award is a Phase I grant from the National Human Genome Research Institute (NHGRI) to develop Nanobind methods for tunable size selection purification in next-generation sequencing library preparation. Nanobind can be used for reaction cleanup to remove small background molecules such as adapters and primer dimers. However, Nanobind’s unique binding mechanism also allows it to perform tunable size selection of much larger library products to enhance sequencing read lengths. All Nanobind methods use a simple bind, wash, and elute process that features high purification and high recovery efficiencies.

The second award is a Phase II grant from the National Institute of Environmental Health Sciences (NIEHS) to develop Nanobind methods that can obtain high quality DNA from formalin-fixed, paraffin embedded (FFPE) tissue samples and cytology samples. Phase I studies showed that Nanobind could obtain high quality DNA and RNA from a wide variety of clinical pathology samples. These studies further found that under specific conditions, Nanobind could uniquely obtain high molecular weight DNA (>100 kb) as well. Phase II work will focus on maturation of the Nanobind methods to further improve DNA and RNA quality. As part of this work, Circulomics will begin development of a new portfolio of assays to quantitatively assess DNA quality.

According to CEO Dr. Kelvin Liu, “We see great opportunity in new sample preparation, sequencing library preparation, and sample quality assays that can improve the yield and quality of next-generation sequencing data.”

These awards bring total funding to nearly $8M and drive the expansion of Circulomics’ growing portfolio of sample preparation technologies for genomics research and molecular diagnostics that include Nanobind nucleic acid purification, sample quality assays, and the PicoSep single molecule DNA sizing instrument.

Read the full story at http://www.prweb.com/releases/2017/10/prweb14767226.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related biology technology :

1. Bioarray Genetics Receives $4M in Series B Equity Financing
2. GeneOne Life Science Receives Approval for Phase I/IIa MERS-CoV Vaccine Trial in Korea
3. SFC Fluidics, Inc. Receives SBIR Phase II Funding for Development of an Implantable Drug Delivery Device
4. Heidelberg Instruments receives orders for advanced VPG+ Volume Pattern Generator from two Asian based photomask suppliers
5. Worcester Polytechnic Institute Receives National Institutes of Health Funding to Develop a Heart Muscle Patch
6. Benchworks Receives Industry Accolades
7. Kibow Biotech Inc. (Buzz of Bio Winner, 2014) Receives US Patent for Gout/Hyperuricemia Product Formulation Based on Modulation of the Gut Microbiome With Probiotics and Prebiotics
8. Heidelberg Instruments receives order for an advanced VPG Large Area Volume Pattern Generator
9. G-CON Manufacturing CEO Receives Recognition as a Top Pharmaceutical Industry Influencer
10. Worcester Polytechnic Institute Receives $1.6 million NIH Award to Study Gender Differences in Neurobiology
11. Singota™ Solutions CEO Receives 2017 Distinguished Alumni Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/10/2017)... SAN DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... website as part of its corporate rebranding initiative announced today. The bold new ... broaden its reach, as the company moves into a significant growth period. , It ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/9/2017)... ... 09, 2017 , ... At its national board meeting in North Carolina, ... University’s Departments of Physics and Astronomy, has been selected for membership in ARCS ... for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating ...
Breaking Biology Technology:
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):