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Circassia Achieves Positive Phase II Clinical Results With Ragweed Allergy T-Cell Vaccine
Date:2/12/2010

our ongoing study in house dust mite allergy later this year," said Steve Harris, Circassia's CEO. "With three phase II studies now complete, our growing clinical database demonstrates the true potential of our ToleroMune T-cell vaccines. Unlike current immunotherapies, which require increasing doses over a number of months and several years of maintenance, ToleroMune therapy is short and simple, and minimises the risk of the severe and sometimes life-threatening side effects associated with many existing treatments."

About Circassia's allergy T-cell vaccines

Circassia's range of allergy T-cell vaccines is based on its proprietary ToleroMune(R) technology. This technology utilises allergen epitopes to generate regulatory T cells that suppress allergic immune responses. Clinical results with Circassia's cat allergy T-cell vaccine show that short treatment regimes can greatly reduce patients' symptoms, without the need for adjuvants or other immune stimulators, while proving extremely well tolerated. As a result, the company's allergy T-cell vaccines offer major potential clinical benefits compared with existing therapies, and consequently have significant market opportunities. Over 150 million people suffer from allergic rhinitis in the US and Europe, and the current treatment market is approximately $12 billion per year.

ToleroMune technology has additional potential regulatory and supply chain benefits. The short peptides utilised in Circassia's vaccines are manufactured chemically, in contrast to existing allergen immunotherapies, which are purified from natural sources. Circassia's approach applies the chemistry, manufacturing and control standards associated with conventional pharmaceuticals to its allergy T-cell vaccines. This fits with changes in the European regulatory environment, where authorities are increasin
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SOURCE Circassia Ltd
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