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Circassia Achieves Positive Phase II Clinical Results With Ragweed Allergy T-Cell Vaccine
Date:2/12/2010

OXFORD, England, February 12 /PRNewswire/ -- Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced that its ToleroMune(R) ragweed allergy T-cell vaccine achieved positive results in a recently completed phase II clinical trial. Ragweed allergy is particularly common in America, where it affects approximately 25% of the population. Circassia's latest clinical results follow two earlier successful phase II studies with the company's T-cell vaccine against cat allergy. The company has three additional phase II trials ongoing, targeting house dust mite and cat allergies, and plans to initiate three further studies in the coming months, extending the portfolio into the field of grass allergy.

The results from Circassia's latest clinical study demonstrate that four doses of the ToleroMune T-cell vaccine greatly improved the allergic responses measured in the trial. The efficacy endpoints, which included the early phase skin response to a challenge dose of ragweed allergen, were measured both before and after the ragweed season. This response, which is commonly used by allergists to assess allergic status, showed a characteristic increase in the placebo group by the end of the ragweed season, resulting in values 37% higher than baseline. In contrast, the optimal ToleroMune T-cell vaccine regime reversed this seasonal increase and reduced it by a further 47% compared with the pre-ragweed season baseline. Throughout the study, the ToleroMune vaccines were safe and well tolerated, with a treatment-related safety profile similar to placebo.

"These highly encouraging clinical results further validate our unique T-cell vaccine approach to allergy therapy. Our ToleroMune technology has now shown its potential to address both ragweed and cat allergies, and we hope to extend this product range when we receive the results of
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SOURCE Circassia Ltd
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