Navigation Links
Chronic Hepatic Diseases Generate High Costs to Europe
Date:4/19/2012

orsening of patients' health, direct and indirect costs.

In a separate study the EASL-CLIF consortium report that 28 day mortality for Acute-on-Chronic liver failure (ACLF) is 35.5%[2]. The consortium set out to address questions around ACLF, a poorly defined syndrome characterized by acute deterioration of cirrhosis, representing a main cause of hospitalisation and death. At present, no diagnostic criteria and information on prevalence, pathogenesis or prognosis are available. The consortium aimed to develop a new score (CLIF-SOFA, derived from the existing sequential organ failure assessment score) to assess the severity and number of organ failures.

1,379 patients, admitted to 29 hospitals due to complications of cirrhosis, were enrolled in this observational prospective European CANONIC study. Data presented at The International Liver Congress™2012 reports on results of the first 920 cases.


Four grades of ACLF were identified:

  • ACLF-1: renal failure or a nonrenal organ failure associated with creatinine 1.5-2 mg/dL and/or grade I-II encephalopathy
  • ACLF-2: 2 organ failures
  • ACLF-3: 3 organ failures
  • ACLF-4: 4-6 organ failures

The overall prevalence of ACLFwas 22.6% with twenty-eight-day mortality of ACLF patients at 35.3% compared (but as high as 85.7% in ACLF-4 patients) to only 4.1% in patients without ACLF. ACLF often developed in patients with previously compensated (21%) or recently decompensated (< 3 months, 18%) cirrhosis and was significantly associated with bacterial infections and active alcoholism, but not gastrointestinal hemorrhage. Hepatitis, TIPS, paracentesis without albumin and surgery were infrequent precipitating events. In about 20% of cases no precipitating event was identified. ACLF was associated with an inflammatory reaction (both in infected and not infected patients) as estimated by increased WBC and plasm
'/>"/>

SOURCE European Association for the Study of the Liver
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Riordan Clinic Research Institute Has Developed and Patented a Process for the Assessment of the Energy Metabolism in Patients with Chronic Fatigue Syndrome
2. Study finds chronic abnormal brain blood flow in Gulf War veterans
3. MarketsandMarkets: Chronic Lymphocytic Leukemia Therapeutics Market Worth $2.2 Billion by 2020
4. Natures Bioceuticals Enters Chronic Obstructive Pulmonary Disease Market After Acquiring Breakthrough Breathing Formula
5. "PATH B": A Comprehensive Support Programme in Europe for Patients Diagnosed With Chronic Hepatitis B Launched
6. BioDelivery Sciences Announces Results from Phase 3 Efficacy Study for BEMA Buprenorphine in Chronic Pain
7. GeNO LLC Receives Federal Grant To Advance Studies of Inhaled Nitric Oxide Product for the Treatment of Chronic Pulmonary Diseases
8. BioDelivery Sciences Announces Completion of BEMA Buprenorphine Phase 3 Chronic Pain Study
9. Cebixs Long-Acting C-Peptide Ersatta™ has Potential in Multiple Chronic Complications of Diabetes
10. Work by UH evolutionary biologist may one day help with chronic diseases
11. Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... Orlando, Florida (PRWEB) March 31, 2015 ... announced the official relocation of their U.S. facilities and ... more than 25 years of experience, Cryos’ relocation is ... presence. , The move to Orlando was completed during ... with an official opening taking place on April 6. ...
(Date:3/30/2015)... 2015  Multiple new research abstracts suggest walnuts may ... factors. From their impact on colon cancer and certain ... both gut health and vascular health, the research findings ... understanding of walnuts, inner workings. Running March 28 through ... annual meeting attracts an international audience of over 14,000 ...
(Date:3/30/2015)... Md. , March 30, 2015 CASI ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a commercial focus on ... Food and Drug Administration (CFDA) has approved the Company,s ... in ovarian clear cell carcinoma (OCCC) patients for its ...
(Date:3/30/2015)... March 30, 2015 Immunocore ... drugs to treat cancer, viral infections and autoimmune ... John Bell , the Regius Professor of ... Office for the Strategic Coordination of Health Research, ...      (Photo: http://photos.prnewswire.com/prnh/20150330/736483 ) ...
Breaking Biology Technology:Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2New Findings Support the Benefits of Eating Walnuts on Overall Health 2New Findings Support the Benefits of Eating Walnuts on Overall Health 3New Findings Support the Benefits of Eating Walnuts on Overall Health 4CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 2CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 3CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 4CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 5Immunocore Appoints Professor Sir John Bell to its Board of Directors 2Immunocore Appoints Professor Sir John Bell to its Board of Directors 3Immunocore Appoints Professor Sir John Bell to its Board of Directors 4Immunocore Appoints Professor Sir John Bell to its Board of Directors 5
... Microscopic robots crafted to maneuver separately without any obvious ... of continuing research led by a Duke University computer ... assembly and control at this fine a resolution with ... Duke professor of computer science and biochemistry. , Each ...
... Pharmaceuticals,Inc. (Nasdaq: AMLN ) today announced that ... diabetes drugs, BYETTA(R) (exenatide) injection and,SYMLIN(R) (pramlintide acetate) ... at the American Diabetes Association,s 68th Annual,Scientific Sessions ... June 6 to,10. The company will also host ...
... June 2 , CALL DATE: Tuesday, June 3, 2008, ... Time, HOST: Dr. Candace ... conduct a telephone conference call and,simultaneous webcast on Tuesday, June 3 ... Research Corporation that,was announced on May 30 and to provide an ...
Cached Biology Technology:Microrobots dance on something smaller than a pin's head 2Microrobots dance on something smaller than a pin's head 3Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 2Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 3Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 4Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 5Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 6Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 7Kendle to Host Conference Call and Webcast to Discuss DecisionLine Acquisition and Provide Update on Second Quarter Progress 2
(Date:3/24/2015)... WASHINGTON , March 24, 2015   NexID ... applications with critical security-authentication needs, today announced the beginning ... fake-finger-detection (FFD) solution. The company, based in ... announcement at the three-day Connect:ID Expo, which began here ... NexID said version 2.0 of its SDK boosts ...
(Date:3/23/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... television starting March 30 th . ... New York markets. ... about our new ad campaign following the recent initial shipment ...
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... WI, JANUARY 5, 2009 Currently, plant testing ... risks from chemical pesticides to nontarget plants requires ... Protection of the plant development and reproduction are ... of animals. Past research conducted by the USEPA ...
... UNDERSTANDING GENETIC AND SOCIOECONOMIC DIFFERENCES,CAREFREE, AZ,FEBRUARY 3-6, 2009 ... ethnic differences in treatment and outcomes among cancer ... the underlying causes and what can be done ... Association for Cancer Research is hosting a collaboration ...
... long suffered an identity crisis. Pop culture heedlessly ... dinosaurs. Even paleontologists assumed that because the creatures flew, they ... legs to take flight. Now comes ... 500 pounds of reptilian heft into flight required pterosaurs to ...
Cached Biology News:American Association for Cancer Research hosts Science of Health Care Disparities Meeting 2Four, three, two, one . . . pterosaurs have lift off 2
...
Human Cell Line Slides...
... Immunogen: Synthetic peptide derived from ... junctophilin-1. Specificity: Specific for the ... controls: mouse brain and skeletal muscle ... muscle tissues). Applications: Western blotting ...
Request Info...
Biology Products: