Navigation Links
Chromosome breakpoints contribute to genetic variation
Date:4/23/2009

n within the breakpoint regions contribute to the evolution of an organism's genome, Lewin said. Breakages sometimes disrupt genes or gene families that are regulated together, for example. Deletions, insertions and inversions can cause subtle or dramatic changes in how the genes function.

Scientists once hypothesized that chromosomal breakage and recombination occurred randomly along the chromosomes during evolution. But in 2003, a team from the University of California at San Diego and the Lewin laboratory reported that the breakpoints occurred more often in specific chromosomal regions than in others.

In 2004, Lewin and his colleagues reported a surprising finding: Breakpoint regions also contain a higher density of genes than other parts of the chromosome. In 2005, Lewin's team showed that breakpoint regions also have higher numbers of segmental duplications, a type of mutation that increases the copy number of genes and the sequences that flank them.

"To me, this was completely counterintuitive. I thought we would have these breakpoints in gene deserts," Lewin said. "We had to rethink the whole evolutionary hypothesis about what was going on in breakpoints."

In the new study, Denis Larkin, a senior scientist on Lewin's team, compared the chromosomes of nine mammals (human, chimp, macaque, rat, mouse, pig, cattle, dog, opossum) and a chicken. He found that the breakpoint regions contained many more copy number variants, insertions and deletions in their sequences than the other parts of the chromosomes. Such variations appear to make these regions more susceptible to breakage, Lewin said. (The chromosome analysis was facilitated by Evolution Highway, a powerful software tool developed in collaboration with Michael Welge and Loretta Auvil at the National Center for Supercomputing Applications at the University of Illinois.)

The researchers also found that different classes of genes appear in the breakpoint and break-re
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology technology :

1. New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human
2. Genencor Shows How Industrial Biotech Breakthroughs Contribute to the New Green Economy
3. Monsantos Historic R&D Investment has Contributed to Mid-20s Gross Profit Growth for Its Seeds and Genomics Segment
4. Lilly Contributes $11.1 Million to United Way Annual Campaign
5. Baxter and Its Foundation Contribute Nearly $53 Million in 2007 to Address Critical Needs Locally and Globally
6. Monsanto Sees Record Sales in Fiscal Year 2007; Seeds and Traits Business Contributes to Strong Fourth Quarter and Year-End Results
7. AgFeed Industries Enters Into Hog Genetic Program Arrangement with Hypor, the Pig Breeding Division of Hendrix Genetics B.V.
8. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2008 Financial Results
9. SemBioSys Genetics Inc. Announces Clinical Results with Plant-Produced Insulin
10. Interleukin Genetics Reports Fourth Quarter and Year End 2008 Financial Results
11. Genetic discovery could lead to advances in dental treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chromosome breakpoints contribute to genetic variation
(Date:5/22/2013)... Cambridge Semantics was one of just 22 companies ... Capitol Hill, hosted by The Data Transparency ... showcase how innovative data management applications can address the requirements ... , Originally introduced in 2011 by Committee Chairman ... Warner (D-VA ), the DATA Act is designed to ...
(Date:5/22/2013)... 2013  Superior Controls, Inc. has been named ... NH Magazine.  For the past 22 years, the ... themselves with extraordinary business and civic excellence. ... honor," said Rick Pierro , ... this award is a reflection of Superior Controls, ...
(Date:5/22/2013)... 2013 AudioNotch is ... tinnitus treatment. AudioNotch is pleased to announce a ... locations in both British Columbia and Alberta, Destination ... hearing services. AudioNotch's tinnitus treatment program is now ... a Destination Hearing clinic, patients have the detection ...
(Date:5/22/2013)... 2013 Envera announced today that Michael ... Mr. McErlean has an extensive background in cell production ... his career. , Mike Matheny, President and ... have Mike join our team”. “Mike’s background is perfectly ... fermentation and downstream processing equipment”, added Matheny. “Mike’s ...
Breaking Biology Technology:Cambridge Semantics Underscores Need for Smart Data during “Data Demonstration Day” on Capitol Hill 2Superior Controls of Seabrook, NH named Business of the Year for 2013 by Business NH Magazine 2AudioNotch Tinnitus Treatment Launches Partnership With Destination Hearing 2Envera Appoints Michael McErlean Fermentation Manager 2
... Increases Risk of Breast Cancer, PARSIPPANY, N.J., Sept. ... 30 pounds between your teens and your 50s could ... word is getting out about the,link between excess weight ... those extra pounds and improve their health, but to ...
... that genetically modified cotton, altered to express the insecticide, Bt, ... reduces pests among other nearby crops that have not been ... for controlling pests and maximizing crop yields in the future. ... Science on Friday, 19 September. Science ...
... consists of billions of cells that continually transmit signals ... us to learn, remember, and so much more − ... or, in other words, when there is a good ... controlled protein production along with the synapse. VIB researchers ...
Cached Biology Technology:alli(TM) Partners with Breast Cancer Network of Strength(TM) to Support Women Challenged by Breast Cancer, Weight Loss or Both 2alli(TM) Partners with Breast Cancer Network of Strength(TM) to Support Women Challenged by Breast Cancer, Weight Loss or Both 3GM crops protect neighbors from pests 2Revealing the regulating mechanism behind signal transduction in the brain 2
(Date:5/22/2013)... biodiversity of pollinating insects and wild plants have slowed ... Researchers led by the University of Leeds and the ... of dramatic reductions in the diversity of species in ... 1980s. , But the picture brightened markedly after 1990, ... among bees, hoverflies and wild plants. , ...
(Date:5/21/2013)... Wash. A new analysis shows that the nation,s ... of enough algae to produce up to 25 billion ... States, one-twelfth of the country,s yearly needs. , The ... resources that would be needed to grow significant amounts ... results were published in the May 7 issue of ...
(Date:5/21/2013)... Center today awarded 12 research grants, totaling nearly ... efforts. , The two-year grants of up to ... track the remediation of harmful algae blooms; assess ... plant invasions; study chromosomal damage in tree swallow ... , The grants were awarded to multidisciplinary teams ...
Breaking Biology News(10 mins):Encouraging signs for bee biodiversity 2Encouraging signs for bee biodiversity 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 4U-M Water Center awards $570K in Great Lakes restoration grants 2U-M Water Center awards $570K in Great Lakes restoration grants 3U-M Water Center awards $570K in Great Lakes restoration grants 4
... the function of microRNAs developed by a Hebrew University of ... new mechanism by which viruses evade the human immune system. ... battle between viruses and humans. For her work in ... of the Faculty of Medicine at the Hebrew University and ...
... us at a daylong event to help forge an ... protecting scientists from political meddling and corporate influence. Dr. ... Space Studies, will speak on the "Threat to the ... Dr. Hansen is considered the world,s leading authority on ...
... slow moving purple sea urchin may look oblivious, lacking ... an impressive suite of sensory receptors to detect outside ... has much more ammunition to activate its innate immune ... in coastal areas that face increasing pollution, and it ...
Cached Biology News:Hebrew University study opening new route for combating viruses 2NASA scientist James Hansen to speak at July 11 conference on 'Rejuvenating Public Sector Science' 2Genomics of large marine animals showcased in the biological bulletin 2Genomics of large marine animals showcased in the biological bulletin 3
Request Info...
Anti-Bcl-G (CT) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C...
Polyclonal antiserum raised against conjugated L-isoleucine. Available as antiserum. Amino Acid Antibodies...
Mouse monoclonal [002-49] to C1s ( Abpromise for all tested applications). entrezGeneID: 716 SwissProtID: P09871...
Biology Products: