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Chimerix's PIM Conjugate Technology Reduces Risk of Nephrotoxicity for CMX001 and CMX157
Date:11/16/2010

or the treatment of cytomegalovirus retinitis, and as Viread® (tenofovir disoproxil fumarate) for the treatment of HIV.

These data were presented in a poster titled "Lipid Conjugates of Cidofovir and Tenofovir, CMX001 and CMX157, Are Not Substrates of Human Organic Anion Transporters hOAT1 and hOAT3" (Abstract T3396) at the FIP Pharmaceutical Sciences World Congress and AAPS Meeting being held in New Orleans, LA.  A copy of the poster is available on Chimerix's website at http://www.chimerix.com.

About Chimerix and CMX001

Chimerix is developing novel antiviral therapeutics with the potential to transform patient care in multiple settings, including transplant, oncology, acute care and global health.  

The company's lead candidate, CMX001, is in Phase 2 clinical studies in immunocompromised transplant and cancer patients for the treatment of life-threatening viruses, including cytomegalovirus and adenovirus.  Over 300 people have received CMX001 to date.  CMX001 has been well tolerated in all studies, with a growing body of evidence of the compound's antiviral activity in humans.  In Chimerix's ongoing placebo-controlled studies, CMX001 has been administered to more than 200 patients and healthy volunteers.  In addition, at the request of leading physicians at over 45 medical centers throughout the United States, Canada, Europe and Israel, CMX001 has been administered to more than 120 patients under investigator-held Emergency Investigational New Drug applications (EINDs) for the treatment of a wide range of infections caused by dsDNA viruses for which there are either no approved treatments or where patients have failed the available treatment.  To date, CMX001 has been used to treat patients with 12 different dsDNA viral infections across all five families of dsDNA viruses that affect humans. CMX001 is also being developed as a medical countermeasure in
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SOURCE Chimerix, Inc.
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