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Chimerix's PIM Conjugate Technology Reduces Risk of Nephrotoxicity for CMX001 and CMX157
Date:11/16/2010

NEW ORLEANS, and RESEARCH TRIANGLE PARK, N.C., Nov. 16, 2010 /PRNewswire/ -- Scientists from Chimerix, Inc. today presented in vitro data demonstrating that the company's lipid-conjugated drugs, CMX001 and CMX157, are not substrates for the human Organic Anion Transporters (hOATs) and thus have significantly reduced potential to cause nephrotoxicity via this mechanism.  These data, presented at the International Pharmaceutical Federation (FIP) Pharmaceutical Sciences World Congress (PSWC 2010) and American Association of Pharmaceutical Sciences (AAPS) Annual Meeting, provide a mechanistic explanation for the observed absence of nephrotoxicity in human clinical testing of both compounds to date.  Nephrotoxicity is a significant dose-limiting factor for several comparable therapies.

Chimerix is applying its powerful PIM (Phospholipid Intramembrane Microfluidization) Conjugate Technology to existing antiviral compounds to create new chemical entities with improved pharmaceutical attributes.  The PIM Conjugate Technology is used to modify a drug molecule so that it mimics a naturally occurring phospholipid.  The lipid mimic can then utilize natural uptake pathways enabling oral bioavailability and altering drug distribution profiles. Chimerix's lead clinical candidate CMX001 applies Chimerix's PIM Conjugate Technology to the antiviral agent cidofovir, while the second clinical stage compound, CMX157, is the company's proprietary lipid conjugation of tenofovir.  Both cidofovir and tenofovir are known to cause nephrotoxicities, and the severity of nephrotoxicities associated with cidofovir in particular have substantially limited its use.  Chimerix has created CMX001 and CMX157 with the intent of minimizing this serious side effect while enhancing drug bioavailability and antiviral activity.  

The study reported at the World Congress was designed to evaluate whether CMX001 and CMX157 are substrates of human O
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SOURCE Chimerix, Inc.
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