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Chimerix and BARDA Reach Agreement Ending GAO Review of Smallpox Antiviral Contract
Date:6/27/2011

to have reached a rapid resolution of the GAO protest so that all parties can continue with the important work of developing smallpox antivirals," said Kenneth I. Moch, President & CEO of Chimerix.  "Chimerix is intensely focused on developing CMX001, for its dual-use potential and as a potent broad spectrum antiviral, to address the threat of smallpox release and the critical needs of immunosuppressed transplant and oncology patients with life-threatening viral infections."

About CMX001

CMX001 is being developed as a potential broad spectrum oral antiviral for the treatment of life-threatening double-stranded DNA (dsDNA) viral diseases, including herpes viruses, adenoviruses and orthopox viruses.  The growing body of evidence of CMX001's antiviral activity against all five families of dsDNA viruses that cause morbidity and mortality in humans, including smallpox, has strengthened the compound's potential as a dual-use product prescribed as a traditional pharmaceutical and stockpiled as a biodefense countermeasure. More than 500 patients have been dosed with CMX001 to date in ongoing placebo-controlled clinical trials and in open-label treatment protocols for the prophylaxis, preemption and treatment of dsDNA viral diseases.  250 patients have received CMX001 under Emergency Investigational New Drug Applications (EINDs), including for treatment of orthopox viruses.  A significant number of the individuals receiving CMX001 in human testing have been immunocompromised as a result of disease or immunosuppressing therapies associated with stem cell or solid organ transplantation.

Clinical studies of CMX001 include: an ongoing Phase 2 study of the prevention/control of cytomegalovirus (a herpes virus) in adult hematopoietic stem cell transplant patients (CMX001-201); a Phase 2 study currently being initiated for the treatment of adenovirus infection in pediatric and adult hematopoietic stem cell transplant patients (AdV
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Related biology technology :

1. Chimerix to Present at Two Upcoming Investor Conferences
2. Chimerix Awarded BARDA Contract for Advanced Development of Broad Spectrum Antiviral CMX001 as Medical Countermeasure Against Smallpox
3. Chimerix Completes $45 Million Financing to Fund Further Development of Novel Antiviral Therapeutics CMX001 and CMX157
4. Chimerix Presents Update on CMX001 Development to the World Health Organization Advisory Committee on Variola Virus Research
5. Chimerixs PIM Conjugate Technology Reduces Risk of Nephrotoxicity for CMX001 and CMX157
6. Chimerix Appoints Two New Vice Presidents to Clinical Management Team
7. Chimerix to Present at Upcoming Investor Conferences
8. Chimerix Initiates Phase 1 Study of CMX157
9. Chimerix Names George Painter, Ph.D., Chairman of the Board and Chief Scientific Officer; Appoints Kenneth I. Moch President and Chief Executive Officer
10. Chimerix Names Wendy Painter, M.D., M.P.H., as Chief Medical Officer
11. Chimerix, Inc. Appoints Kenneth I. Moch Chief Operating Officer
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