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Chimerix Presents Update on CMX001 Development to the World Health Organization Advisory Committee on Variola Virus Research
Date:11/17/2010

GENEVA and RESEARCH TRIANGLE PARK, N.C., Nov. 17, 2010 /PRNewswire/ -- Chimerix, Inc., a pharmaceutical company developing orally-available antiviral therapeutics, today presented an update to the World Health Organization (WHO) on the development of the company's lead antiviral compound, CMX001, at the 12th Meeting of the WHO Advisory Committee on Variola Virus Research in a presentation titled "Status of CMX001 for Smallpox and Other dsDNA Viruses."  CMX001 is being developed for dual-use as a medical countermeasure in the event of a smallpox release and as a broad-spectrum antiviral for the treatment of life-threatening viruses in immunocompromised transplant and cancer patients.

"Chimerix is passionate about the need to develop effective antiviral therapeutics to improve global health and protect against viral threats such as smallpox.  Therefore, we are pleased by the opportunity to provide an update to the World Health Organization on the significant progress being made in the development of CMX001 as a potential dual-use agent," commented Wendy Painter, M.D., M.P.H., Chief Medical Officer of Chimerix.  "In addition to proven efficacy in numerous animal studies against pox viruses, we are amassing a significant body of clinical data in critically-ill patients regarding CMX001's safety and antiviral activity against double-stranded DNA viruses."

CMX001 is currently in Phase 2 clinical trials for prophylaxis of human cytomegalovirus infection and under development using the FDA's "Animal Rule" for smallpox infection.  It has proven effective in reduction of morbidity and mortality in animal models of smallpox, even when treatment is initiated after the onset of lesions.

CMX001 has a number of advantages over other drugs in development for treatment of smallpox, including: broad-spectrum inhibition of double-stranded DNA (dsDNA) viruses that cause human disease; a high barrier to resistance; convenient oral administrati
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SOURCE Chimerix, Inc.
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