Navigation Links
Chimerix Initiates Phase 1 Study of CMX157
Date:5/13/2010

RESEARCH TRIANGLE PARK, N.C., May 13 /PRNewswire/ -- Chimerix, Inc., a biotechnology company developing orally-available antiviral therapeutics, today announced the commencement of a first-in-human study of CMX157, a novel lipid conjugate of the nucleotide tenofovir with in vitro activity against both tenofovir-sensitive and tenofovir-resistant human immunodeficiency virus (HIV). CMX157 has the potential to increase efficacy and decrease toxicity as compared to tenofovir, and may enable the creation of new 'one pill, once-a-day', fixed-dose combination regimens for the treatment of HIV infection.

The Phase 1 dose-escalating clinical study is designed to evaluate the safety, tolerability and pharmacokinetics (PK) of CMX157. Healthy volunteers will receive a single-dose of CMX157 (25 mg, 50 mg or 100 mg), a standard dose of tenofovir (as Viread®) or placebo. In addition to monitoring safety and standard PK parameters in plasma, levels of the active antiviral (tenofovir diphosphate) will be determined in peripheral blood mononuclear cells (PBMCs). These data will provide insight into the potential efficacy of CMX157, as the levels of tenofovir diphosphate in PBMCs associated with the antiviral efficacy of Viread have been documented.

"We are pleased to advance CMX157 into human clinical studies. While advances in HIV treatment have resulted in longer life spans, HIV is known to develop resistance to currently approved agents and significant drug side effects remain an issue for many patients," said Wendy Painter, M.D., MPH, Chimerix's Chief Medical Officer. "We are extremely encouraged by preclinical data that show CMX157 to be highly potent and less toxic than current HIV drugs and believe it has the potential to become an important new antiviral therapy."


'/>"/>
SOURCE Chimerix, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Chimerix Names George Painter, Ph.D., Chairman of the Board and Chief Scientific Officer; Appoints Kenneth I. Moch President and Chief Executive Officer
2. Chimerix Names Wendy Painter, M.D., M.P.H., as Chief Medical Officer
3. Chimerix, Inc. Appoints Kenneth I. Moch Chief Operating Officer
4. Chimerix Joins International Network of Organizations to Cure Malaria
5. Chimerix Completes Phase I Study and Initiates a Phase II Multi-dose Clinical Trial for CMX001
6. Merial to Screen Chimerix Chemical Library for Animal Health Drug Leads
7. Chimerix Appoints Neil Frazer, M.B., Ch.B., FRCA, FFPM as Chief Medical Officer
8. Sanofi-aventis Initiates 10,000 Patient Study With Multaq(R) in Permanent AF
9. EnVivo Initiates Phase IIb Alzheimers Disease Trial For EVP-6124
10. Harbinger Research Initiates Coverage on China Baicaotang Medicine, Ltd.
11. Merrimack Pharmaceuticals Initiates Enrollment in Phase 1/2 Combination Study of MM-121 and Tarceva in Patients with Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 2014 Gain recognition for leadership ... of the biotech industry. Nominations are now being ... to you by the Bio Supply Management ... chain management professionals for the past 7 years. ... the Biotech industry – Manufacturers, Service Providers, Material ...
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... trained personnel, and detection dogs to safeguard airports ... revolutionary new electronic chip with nano-sized chemical sensors ... , The groundbreaking nanotechnology-inspired sensor, devised by Prof. ... of Chemistry and Center for Nanoscience and Nanotechnology, ... up the scent of explosives molecules better than ...
(Date:7/24/2014)... scientists are making progress in devising suitable means ... relies on quantum dotsa kind of artificial atom, ... new study demonstrates that changing the coupling of ... impulses can help better control them. This has ... quantum information units, which would produce faster quantum ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... Remove >90% of mammalian RNA from , ... Simple procedure takes less than 2 hours , ... Seamless integration with , MICROB Express ... microarray expression analysis with , bacterial RNA isolated from host cells ...
... , , ... methods to isolate high quality RNA from a large number of ... the RNAqueous-96 , Kit . This kit, which ... of intact RNA in a 96-well plate format. An optional on-the-filter , ...
... Amplification Kits-- Now Available with Cy Dyes , ... Extremely sensitive , ArrayScript Reverse , ... yields , ... 4000-fold amplification of mRNA , Optimized buffers--high dye coupling efficiency , ...
Cached Biology Technology:Bacterial RNA Isolation From Infected Eukaryotic Hosts 2Bacterial RNA Isolation From Infected Eukaryotic Hosts 3Bacterial RNA Isolation From Infected Eukaryotic Hosts 4Bacterial RNA Isolation From Infected Eukaryotic Hosts 5Bacterial RNA Isolation From Infected Eukaryotic Hosts 6Automating RNA Isolation 2Automating RNA Isolation 3Automating RNA Isolation 4Automating RNA Isolation 5aRNA Synthesis and Labeling for Array Analysis 2aRNA Synthesis and Labeling for Array Analysis 3aRNA Synthesis and Labeling for Array Analysis 4aRNA Synthesis and Labeling for Array Analysis 5
(Date:7/24/2014)... Angeles, where electric cars ply silent freeways, solar panels ... beneath the earth, from howling winds and from the ... that it is technically and economically feasible to convert ... renewable energy. Published in Energy , the plan ... energy supply in California that could create tens of ...
(Date:7/24/2014)... 24, 2014 Some sticky research out of York ... a certain species of toxic grass fungus: moose saliva ... Biology Letters , "Ungulate saliva inhibits a grassendophyte ... to red fescue grass (which hosts a fungus called ... slower fungus growth and less toxicity. , "Plants have ...
(Date:7/24/2014)... of researchers has developed a new nanoscale agent for ... for assessing the function and properties of the GI ... and treatment of gut diseases. , Illnesses ... and inflammatory bowel disease all occur in the intestine ... with diseases such as diabetes and Parkinson,s. , ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4Moose drool inhibits growth of toxic fungus: York U research 2New imaging agent provides better picture of the gut 2
... Inc., today announced that its 12,200 Online Books ... of HINARI, AGORA and OARE, benefitting research and ... including Malawi, Cambodia, and Bolivia. Research4Life provides ... low cost access to peer-reviewed online content from ...
... /PRNewswire-iReach/ -- Successful businesses stay connected to the ... with industry leaders at global biotech conferences with ... go to learn about new innovations, how to ... and risks while overcoming regulatory and technological hurdles. ...
... by English naturalist Charles Darwin on the Galapagos Islands, ... as isolation on a particular island, can lead to ... natural selection. Natural selection is a process whereby ... successive generations, while unfavorable heritable traits become less common. ...
Cached Biology News:Over 12,000 Wiley Online Books made available in developing countries via Research4Life 2Early Bird Conference Registrations Expiring This Friday 2Early Bird Conference Registrations Expiring This Friday 3Early Bird Conference Registrations Expiring This Friday 4LSU professor discovers how new corals species form in the ocean 2LSU professor discovers how new corals species form in the ocean 3
Request Info...
See product name for description....
... Amino acid mixture excluding l-[U-14C]methionine, ... containing 2% ethanol, sterilized. > ... mCi/mg atom carbon. Mixture of ... Ile, Leu, Lys, Phe, Pro, Ser, ...
Request Info...
Biology Products: