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Children's Oncology Group and Apeiron to Jointly Conduct Phase II Study in Neuroblastoma With hu14.18-IL2 (APN301)

sitive tumor cells via the antibody component. The fused IL2 is designed to stimulate the patient's immune system against the tumor by activation of both NK and T cells, whereas the Fc portion of the antibody is designed to trigger tumor cell killing by ADCC (antibody-dependent cellular cytotoxicity) and CDC (complement-dependent cytotoxicity). Hu14.18-IL2 has shown activity in a phase II clinical study in certain children with neuroblastoma* and was also tested in a phase I/II study in late stage malignant melanoma, showing immune activation. Apeiron has obtained a world-wide exclusive licence for hu14.18-IL2 earlier this year from Merck KGaA.

Contact Children's Oncology Group:
Elizabeth O'Connor, COO
COG Operations Center
440 E. Huntington Drive, 4th Floor
Arcadia, CA 91006-3776
T +1(0)626-447-0064

Contact Apeiron:
Dr. Hans Loibner, CEO    
Campus-Vienna-Biocenter 5
1030 Vienna
T +43(0)1-865-6577

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