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Chiasma Reports Successful Oral Delivery Of A Peptide In Clinical Study
Date:6/13/2010

ry gland, which secretes excess GH and stimulates excess production of insulin-like growth factor I (IGF-I) by the liver, causing tissue growth throughout the body.  The most common signs and symptoms associated with acromegaly include swelling of the hands and feet, enlarged lip, nose, and tongue, joint pain and degenerative arthritis, and an enlarged heart and other organs.  Even well controlled patients have an increased risk for mortality; and in poorly controlled patients, cardiovascular, respiratory, endocrine, and metabolic morbidities result in standardized mortality ratios of 2.5 when compared to non-acromegaly populations.(1)

Injectable (subcutaneous and intramuscular) somatostatin analogs, which bind to somatostatin receptors (SSTR2, SSTR5) to inhibit GH secretion, are the therapeutic standard of care for acromegaly patients who are not cured by resection of the tumor; surgery is the first line of treatment.  GH inhibition by octreotide, one such analog in clinical use, reduces or reverses morbidity and mortality associated with acromegaly.  There is a well-defined correlation between plasma levels of octreotide (pharmacokinetics [PK]) and GH reduction (pharmacodynamics [PD]).  Clinical endpoints include suppression of GH and normalization of IGF-I levels.(2)

Treatment normally begins with subcutaneous injections of the short acting (immediate release) octreotide acetate, three times a day. Once a patient's tolerability and responsiveness to the treatment has been proven, Sandostatin LAR (depot formulation), a monthly IM injection, is usually the treatment of choice for life.  Octreotide is effective for 95% of the patients; approximately 65% and 30% of patients show a complete or partial response, respectively. However, the injections cause discomfort and pain, with 30% to 50% of patients reporting pain at the injection site (for doses of 20 mg and 30 mg Sando
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SOURCE Chiasma, Inc.
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