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Chiasma Reports Successful Oral Delivery Of A Peptide In Clinical Study

in analogs."

Portal Hypertension (PHT) --- A New Indication for Octreolin

In addition, Chiasma announced that it is developing Octreolin also as a chronic treatment for patients with PHT; a trial for this new indication (no drugs are approved for portal hypertension in the US) is expected to start in December of 2010.

How Octreolin Works

Octreolin is a product in capsule form that contains octreotide acetate, a 1.0 kDa peptide, and the Company's unique Transient Permeability Enhancer (TPE) technology. The TPE system allows its drug cargo to cross mucosal epithelia in the small intestine by inducing a temporary opening of the Tight Junctions that seal and regulate passage between cells (the paracellular route). This effect on the epithelia is rapid and fully reversible. The drug reaches the bloodstream effectively in its native active form.

TPE activity is the result of a unique combination of excipients assembled in a process leading to a suspension of hydrophilic particles in a lipophilic medium. Chiasma has developed a unique, simple and cost effective production process that ensures safety and stability of its drug products; all components used in manufacturing of the drug product are approved for pharmaceutical use. The TPE technology is versatile, can be applied to a wide range of therapeutic agents and requires no chemical modification of the drug.

About Acromegaly

Acromegaly is an endocrine condition associated with a benign adenoma in the pituita

SOURCE Chiasma, Inc.
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