MOUNTAIN VIEW, Calif., Nov. 10, 2011 /PRNewswire/ -- ChemoCentryx, Inc. today announced positive preclinical results for its novel CCR2 antagonist at the 44th Annual Meeting of the American Society of Nephrology. CCR2 inhibition in diabetic mice resulted in rapid and robust improvements of albuminuria, serum markers of renal function, and hyperglycemia. These data were highlighted today in a poster presentation titled "CCR2 Inhibition in Diabetic Mice Results in a Rapid and Robust Improvement of Renal Function" in Philadelphia, PA. CCX140, the Company's most advanced CCR2 antagonist is currently in Phase II clinical trials for diabetic nephropathy.
"These results further support the clinical evaluation of CCR2 antagonists such as our lead independent drug candidate, CCX140, in renal disease," stated Thomas J. Schall, President and CEO, ChemoCentryx. "Diabetic nephropathy is the leading cause of end-stage renal disease, for which there are no current treatment options that halt or reverse disease progression. We believe CCR2 antagonism represents a potential new treatment option which would delay or prevent the onset of end-stage renal disease and therefore offer significant pharmaco-economic benefits."
Results and Study Design
Results show that treatment with a CCR2 inhibitor significantly reduced urinary albumin excretion (UAER) and albumin:creatinine ratio (ACR). Statistically significant improvements in UAER and urinary ACR were noted as early as 48 hours after initiation of treatment. Serum markers of renal function (serum creatinine and blood urea nitrogen) were also improved after 14 days of treatment. The benefits seen on renal function were observed at lower doses than those required for anti-glycemic benefit.
Male db/db mice (age 12-19 weeks) were dosed daily with the CCR2 antagonist or matching vehicle. Weekly assessments included body weight, fasting plasma glucose, serum clinical chemistry, and 2
|SOURCE ChemoCentryx, Inc.|
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