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ChemoCentryx Demonstrates Recently Discovered Chemokine Receptor CXCR7 is Essential in Tumor Growth
Date:9/26/2007

d by antibodies that react specifically with CXCR7. The analyses of the human tumors verified that CXCR7 is highly expressed by both the malignant tumor cells and by the tumor-associated blood vessels in the tumor mass, but not found on healthy cells or normal vasculature outside of the tumor mass. These findings were further extended to multiple tumor types, and researchers believe that CXCR7's activity in cancer may be important in a broad range of malignancies. Observations around CXCR7's role in tumor vasculature formation were further evidenced in knockout experiments in a zebrafish model, strongly suggesting that CXCR7 is central to the formation of new blood vessels during development (a process known to resemble aspects of new blood vessel formation in tumors). Taken together, these observations show that CXCR7 may be central to the rapid formation of new blood vessels, a process known as angiogenesis, necessary for tumor growth.

"Drugs targeting tumor angiogenesis represent an important mode of therapy in modern cancer treatment regimens," said Dr. Schall. "Our work shows that CXCR7 may provide an entirely new and powerful target in the approach to future oncology therapy."

EnabaLink Identifies Potent Classes of Chemokine-Based Therapeutics

The data published today result from ChemoCentryx's extensive chemokine drug discovery capabilities and insights into chemokine system biology. CXCR7 is a chemokine receptor that was 'deorphanized' (a function was discovered for the protein encoded by a gene of previously unknown function) at ChemoCentryx through the company's proprietary EnabaLink Drug Discovery(R) engine. Leveraging the EnabaLink suite of technologies, ChemoCentryx is uniquely able to identify highly specific product candidates including orally-active small molecules that bind with high affinity to a specific chemokine receptor. ChemoCentryx has leveraged its EnabaLink Drug Discovery engine for the identification and optimization of e
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SOURCE ChemoCentryx, Inc.
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