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ChemoCentryx Advances Second Orally Available CCR9 Antagonist CCX025 Into Clinical Development
Date:10/15/2008

Solidifies Company's Leadership Position in Targeting Chemokine Receptor

CCR9 for Gastrointestinal Diseases

MOUNTAIN VIEW, Calif., Oct. 15 /PRNewswire/ -- ChemoCentryx, Inc., announced today that it has initiated a Phase I clinical trial of CCX025, the company's fourth investigational new drug and second orally administered compound that inhibits the chemokine receptor known as CCR9. Structurally distinct from Traficet-EN(TM) (CCX282-B; ChemoCentryx's CCR9 antagonist currently in a Phase II/III clinical trial for Crohn's disease), CCX025 strengthens ChemoCentryx's position in the CCR9 arena and expands the company's gastrointestinal franchise with the potential to pursue different clinical indications with discrete compounds.

"With the advancement of CCX025 into the clinic, ChemoCentryx can pursue a greater breadth of diseases associated with CCR9 receptor inhibition with the clear advantage of having two structurally distinct, very potent and highly-selective oral therapeutics," said Thomas J. Schall, Ph.D., President and Chief Executive Officer of ChemoCentryx. "CCX025 is our fourth product candidate in the clinic, all discovered and developed at ChemoCentryx, and establishes our position as a leader in the industry in developing chemokine-based therapeutics."

The Phase I double-blind, placebo-controlled trial of CCX025 is being conducted in healthy male and female volunteers to evaluate the safety, tolerability and pharmacokinetics of CCX025 over a range of dose levels. In preclinical studies, the compound has been shown to be well-tolerated and highly selective. Like Traficet-EN, CCX025 is differentiated from existing inflammatory bowel disease therapies such as biologics (which are typically injected or infused), steroids and immunosuppressives and may offer a novel, safe and conveniently administered treatment option.

CCX025 and Traficet-EN are oral, highly-specific inhibitors of the chemokine receptor kn
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SOURCE ChemoCentryx, Inc.
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