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ChanTest Develops New Cardiotoxicity and Contractility Assay with Human Stem Cell Cardiomyocytes

Cleveland, OH (PRWEB) May 14, 2013

Cardiovascular (CV) toxicity is a leading contributor to drug withdrawal and late-stage attrition in the drug discovery process. There is an urgent need for novel in vitro assays that enable earlier and broader testing for CV activity.

The most relevant cells for pre-clinical testing are human cells. Use of these cells has the potential to add significant efficiencies, reduce animal use and decrease the number of dangerous drugs that reach the market.

In response to this need, ChanTest has developed a new assay using ACEA Bioscience’s xCELLigence System (San Diego, CA) and human induced pluripotent stem cell (iPSC) derived cardiomyocytes from Cellular Dynamics International (CDI, Madison, WI). Based on an extensive research program, ChanTest has created several unique algorithms for twitch detection and kinetic analysis, and has concluded an investigation that suggests twitch impedance is a sensitive tool to assess contraction in a relatively high-throughput assay.

The studies concluded that the impedance twitch recordings accurately reflect key elements of contraction, thus allowing the study of drugs that affect excitation-contraction coupling and the contractile apparatus. In addition, since impedance signals can be recorded over long periods of time, deleterious long-term drug effects, such as those commonly observed for oncology drugs, can be easily evaluated with this label-free procedure. Therefore, the new ChanTest assay, applied to iPSC derived cardiomyocytes, offers an effective non-invasive screen for the cardiotoxicity and contractility.

"We listened to the requests of the pharmaceutical industry for a human cell based cardiotox and contractility assay," explained Chris Mathes, Ph.D., Chief Commercial Officer at ChanTest. "This new assay fulfills that need by combining ChanTest expertise with state-of-the art technology from ACEA and iPSC cardiomyocytes from CDI."

To learn more about the new ChanTest assay using ACEA Bioscience’s xCELLigence system, click here.


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Contact for Media Inquiries:

Chris Mathes, Ph.D., M.B.A.
Chief Commercial Officer

About ChanTest® – The Ion Channel Expert

ChanTest’s mission is to serve the drug discovery and development needs of customers worldwide with high-value solutions for ion channel and GPCR biology. Since its inception in 1998, the CRO has tested compounds for more than 500 global pharmaceutical and biotechnology companies, and partners with them to speed the drug development process for the release of better, safer drugs.

ChanTest offers integrated ion channel and GPCR services (GLP and non-GLP) and reagents; the company’s library of validated ion channel cell lines and nonclinical cardiac risk assessment service portfolio is the most comprehensive commercially available today.

Because of ChanTest’s seminal role in the nonclinical cardiac safety field, along with the company’s uncompromising commitment to quality, ChanTest has been named the “most trusted and most used fee-for-service provider” for ion channel screening in an independent survey for the past eight years. ChanTest is based in Cleveland, Ohio.

Visit to learn more about what we do.

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