Commenting on the benefits of having both ion channel and GPCR expertise under one umbrella, Dr. Baumgold explained, "GPCRs and ion channels interact and one can either trigger or exaggerate the effect of the other. Understanding the mechanisms of action for GPCRs and ion channels individually and together is therefore critical in both drug discovery and safety studies. For example, in the safety arena, it is well known that drugs targeting GPCRs, such as H1 histamine receptors, may produce sudden cardiac death by blocking the cardiac HERG ion channel. ChanTest's scientists pioneered the HERG assay essential to assess this risk. On the discovery side, the central nervous system's 'fight-or-flight' reaction is mediated by cardiac GPCR beta-receptors activating cardiac calcium channels, thereby increasing cardiac pumping. Drugs may affect function of the heart via beta-receptors, calcium channels, or both. We at ACS are honored to become a part of ChanTest - and excited by the prospect of working with our new colleagues to serve our customers better."
ChanTest's acquisition of ACS has been executed to ensure continuity of management, quality science, and service to clients. Customers are encouraged to contact their existing ChanTest or ACS representative to learn about the combined company's expanded portfolio of cell-based assays and reagents, new division-arrested cell lines, membrane preparations, and large cell line scale-up capabilities.
About the New ChanTest - The Ion Channel/GPCR Company (www.chantest.com)
The leading experts in ion channels and GPCR (G-protein coupled receptors) - ChanTest and Applied Cell Sciences (ACS) - are now united to help global pharmaceutical and biotech customers speed the drug-discovery and development process, save time and money, and ultimately - to help make better, safer drugs. The new ChanTest offers integrated ion channel a
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