Dr. Bartus stated, "These data warned us of a fundamental deficiency in Parkinson's disease brains which limits how effectively NRTN is transported from the terminals of degenerating neurons to their cell bodies. This provided the key insight we needed to appreciate the need to directly inject CERE-120 into the substantia nigra (thus reducing dependency on retrograde transport), in addition to injecting a larger dose into the putamen. These dosing changes are intended to help assure that the entire degenerating neuron is exposed to sufficient neurotrophic factor, assuring that a more robust neurotrophic response is stimulated, in turn, further enhancing and accelerating neuronal repair." In June 2010, Ceregene announced that it had successfully completed a new Phase 1 study in Parkinson's patients, intended to provide initial evidence for the safety of this novel dosing paradigm.
Other authors of the paper include Christopher Herzog, Alistair Wilson, Lamar Brown and Joao Siffert (Ceregene, San Diego, CA), Y. Chu, Elliot Mufson and Jeffrey Kordower (Rush University Medical Center, Chicago, IL), Eugene Johnson, Jr. (Washington University, St Louis, MO) and C. Warren Olanow (Mt. Sinai School of Medicine, New York City).
About CERE-120 and its Application to Treating Parkinson's Disease
CERE-120 is composed of an adeno-associated virus (AAV) vector carrying the gene for neurturin, a naturally occurring protein known to repa
|SOURCE Ceregene, Inc.|
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