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Ceregene Reports New Findings Regarding How Parkinson's Brains Respond to Neurotrophic Factors
Date:2/15/2011

he Parkinson's brains versus that seen in nonhuman primates, including contemporary models of Parkinson's disease.  In Parkinson's brains and in nonhuman primate brains, CERE-120 resulted in comparable NRTN expression in the targeted putamen, where the degenerating nerve terminals reside. However, in the case of Parkinson's disease, very little NRTN was seen in the cell bodies of the same degenerating neurons, which are located in a different brain region, called the substantia nigra.

Dr. Bartus stated, "These data warned us of a fundamental deficiency in Parkinson's disease brains which limits how effectively NRTN is transported from the terminals of degenerating neurons to their cell bodies.  This provided the key insight we needed to appreciate the need to directly inject CERE-120 into the substantia nigra (thus reducing dependency on retrograde transport), in addition to injecting a larger dose into the putamen.  These dosing changes are intended to help assure that the entire degenerating neuron is exposed to sufficient neurotrophic factor, assuring that a more robust neurotrophic response is stimulated, in turn, further enhancing and accelerating neuronal repair."  In June 2010, Ceregene announced that it had successfully completed a new Phase 1 study in Parkinson's patients, intended to provide initial evidence for the safety of this novel dosing paradigm.

Other authors of the paper include Christopher Herzog, Alistair Wilson, Lamar Brown and Joao Siffert (Ceregene, San Diego, CA), Y. Chu, Elliot Mufson and Jeffrey Kordower (Rush University Medical Center, Chicago, IL), Eugene Johnson, Jr. (Washington University, St Louis, MO) and C. Warren Olanow (Mt. Sinai School of Medicine, New York City).

About CERE-120 and its Application to Treating Parkinson's Disease

CERE-120 is composed of an adeno-associated virus (AAV) vector carrying the gene for neurturin, a naturally occurring protein known to repa
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SOURCE Ceregene, Inc.
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