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Ceregene Reports New Findings Regarding How Parkinson's Brains Respond to Neurotrophic Factors
Date:2/15/2011

ng scientific rationale for our overall clinical strategy for Parkinson's disease, as well as for the modified dosing paradigm we are employing in our ongoing Phase 2b clinical trial," said Jeffrey M. Ostrove Ph.D., president & chief executive officer of Ceregene.  "We very much appreciate the unselfish courage of patients and the immediate family of patients who volunteer to participate in experimental clinical trials and agree to donate their organs for scientific study after their death.  The information we gained from the brains of two of our study participants was instrumental in significantly improving our understanding of NRTN expression in the PD brain, which then allowed us to enhance our dosing paradigm and continue to move this program forward with confidence of ultimate success."

The paper, entitled "Bioactivity of AAV2-Neurturin Gene Therapy (CERE-120): Differences between Parkinson's Disease and Nonhuman Primate Brains," was further highlighted by a guest editorial commenting on several important elements of the paper.  Additionally, brain images of NRTN expression following CERE-120 treatment in Parkinson's patients were prominently displayed on the front cover of the issue.  The guest editorial (written by Travis Lewis and David Standaert, M.D., Ph.D., University of Alabama, Birmingham) called the paper a "milestone in the development and refinement of neurotrophic factor gene therapy," providing "proof that gene therapy with AAV2-NRTN (aka CERE-120) results in functional...transgene expression in target cells in humans."  The guest editors further opined that "as one of the few therapies immediately available that may not only slow PD expression, but also improve outcomes, we feel that the potential benefits of a clinically successful CERE-120 treatment cannot be ignored."  

Other key findings in the paper resulted from comparing and contrasting the pattern of NRTN expression and bioactivity seen in t
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SOURCE Ceregene, Inc.
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